(R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl) propyl]benzenesulfonamide: the first selective 5-HT7 receptor antagonist

J Med Chem. 1998 Feb 26;41(5):655-7. doi: 10.1021/jm970519e.
No abstract available

MeSH terms

  • Adenylyl Cyclases / metabolism
  • Binding, Competitive
  • Cell Line
  • Gene Expression
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Piperidines / chemical synthesis*
  • Piperidines / pharmacology
  • Receptors, Serotonin / drug effects*
  • Receptors, Serotonin / genetics
  • Receptors, Serotonin / physiology
  • Serotonin Antagonists / chemical synthesis*
  • Serotonin Antagonists / pharmacology
  • Stereoisomerism
  • Structure-Activity Relationship
  • Sulfonamides / chemical synthesis*
  • Sulfonamides / pharmacology

Substances

  • 3,N-dimethyl-N-(1-methyl-3-(4-methylpiperidin-1-yl)propyl)benzenesulfonamide
  • Piperidines
  • Receptors, Serotonin
  • Serotonin Antagonists
  • Sulfonamides
  • serotonin 7 receptor
  • Adenylyl Cyclases