Various drugs are commonly used for the many gastrointestinal problems that are routinely seen in dogs and cats. Many of these drugs are briefly reviewed in this article. Anecdotal as well as documented findings are provided that will hopefully allow the clinician to use them wisely and effectively in the many clinical situations that arise daily. Emetics, although not used for gastrointestinal problems, are also reviewed because of their obvious connection with the gastrointestinal tract.