Synthesis and in vitro anthelmintic activity against Nippostrongylus brasiliensis of new 2-amino-4-hydroxy-delta-valerolactam derivatives

Farmaco. 1997 Oct;52(10):603-8.

Abstract

The synthesis of a series of 2-amino-4-hydroxy-delta-valerolactam derivatives is described (compounds 4 to 10). These compounds showed a high anthelmintic in vitro activity against the Nippostrongylus brasiliensis model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthelmintics / chemical synthesis*
  • Anthelmintics / pharmacology
  • Crystallography, X-Ray
  • Male
  • Molecular Conformation
  • Nippostrongylus / drug effects*
  • Nippostrongylus / growth & development
  • Piperidones / chemical synthesis*
  • Piperidones / pharmacology
  • Rats
  • Rats, Wistar
  • Strongylida Infections / drug therapy
  • Strongylida Infections / parasitology*
  • Structure-Activity Relationship

Substances

  • Anthelmintics
  • Piperidones
  • 2-piperidone