High local production of nitric oxide as a possible mechanism by which rapamycin prevents transplant arteriosclerosis

Transplant Proc. 1998 Jun;30(4):953-4. doi: 10.1016/s0041-1345(98)00107-9.

Authors

S M Pham¹, L L Shears, N Kawaharada, S Li, R Venkataramanan, S Sehgal

Affiliation

¹ Department of Surgery, University of Pittsburgh, PA 15213, USA.

PMID: 9636385
DOI: 10.1016/s0041-1345(98)00107-9

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Aorta, Thoracic / pathology
Aorta, Thoracic / transplantation*
Arteriosclerosis / prevention & control*
Cyclosporine / pharmacology
Enzyme Induction
Immunosuppressive Agents / therapeutic use*
Nitric Oxide Synthase / biosynthesis*
Nitric Oxide Synthase Type II
Polyenes / pharmacology*
Postoperative Complications / prevention & control
Rats
Rats, Inbred ACI
Rats, Inbred WF
Sirolimus
Transplantation, Homologous / immunology
Transplantation, Homologous / pathology
Transplantation, Homologous / physiology*
Transplantation, Isogeneic / immunology
Transplantation, Isogeneic / pathology
Transplantation, Isogeneic / physiology*

Substances

Immunosuppressive Agents
Polyenes
Cyclosporine
Nitric Oxide Synthase
Nitric Oxide Synthase Type II
Nos2 protein, rat
Sirolimus