Cardiopulmonary bypass in a gravid patient: perioperative changes in endothelin levels

Ann Thorac Surg. 1998 Jul;66(1):268-70. doi: 10.1016/s0003-4975(98)00383-x.

Abstract

Transient elevations of the potent vasoconstrictive peptide endothelin have been reported to occur with the institution of cardiopulmonary bypass. We measured plasma endothelin levels in a 24-year-old gravid patient undergoing a mitral valve replacement operation. Plasma endothelin levels increased by more than 250% in the first 24 hours postoperatively and remained elevated above baseline values at 36 hours postoperatively.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Cardiopulmonary Bypass*
  • Endothelins / blood*
  • Female
  • Follow-Up Studies
  • Heart Valve Prosthesis Implantation*
  • Humans
  • Mitral Valve*
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / surgery*
  • Prosthesis Failure
  • Reoperation
  • Thrombosis / surgery

Substances

  • Endothelins