[Effects of intravenous infusion of 5-FU and intraperitoneal injection of low-dose CDDP on 3 cases with ascites owing to peritonitis carcinomatosa of postoperative gastric carcinoma and debility]

Gan To Kagaku Ryoho. 1998 Jul;25(9):1442-4.
[Article in Japanese]

Abstract

We examined the effects of intravenous infusion of 5-FU and intraperitoneal injection of low-dose CDDP on 3 cases with ascites owing to peritonitis carcinomatosa of postoperative gastric carcinoma and debility. Intravenous infusion of 5-FU (250-1,000 mg/body) and intraperitoneal injection of CDDP (20-25 mg/body) carried out for 2-5 days. As a result, QOL of 3 cases was fairly improved. The PS (Performance Status) of 2 cases improved from Grade 4 to 2, and another one improved from Grade 4 to 3. Adverse effects of Grade 1 according to the WHO criteria were observed in 1 case (leukocytopenia and diarrhea). This palliative chemotherapy method appeared to be safe and effective for ascites due to peritonitis carcinomatosa of postoperative gastric carcinoma and debility.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Ascitic Fluid / drug therapy*
  • Ascitic Fluid / etiology
  • Cisplatin / administration & dosage
  • Drug Administration Schedule
  • Female
  • Fluorouracil / administration & dosage
  • Gastrectomy
  • Humans
  • Infusions, Intravenous
  • Infusions, Parenteral
  • Male
  • Middle Aged
  • Peritonitis / drug therapy*
  • Peritonitis / etiology
  • Postoperative Period
  • Quality of Life
  • Stomach Neoplasms / complications*
  • Stomach Neoplasms / surgery

Substances

  • Cisplatin
  • Fluorouracil

Supplementary concepts

  • CF regimen