Human liver cytochrome P-450 and conjugating enzymes. Hungarian data

Abstract

Cytochrome P-450 and the conjugating enzymes of the liver are the most important enzymes in the detoxification of xenobiotics. In order to get direct data in the Hungarian human population the activity of liver cytochrome P-450 enzymes (CYP1A2, 2A6, 2C19, 2D6, E1, 3A4) and of the conjugating enzymes has been determined in 11 Hungarian tissue donors died in accidents or in brain vascular catastrophe, by using specific enzymic reactions. In the activity of cytochrome P-450 enzymes a wide range has been found, a ten-fold difference being rather common. In the activities of conjugating enzymes the differences seem to be less.