Cytotoxic granular protein expression, Epstein-Barr virus strain type, and latent membrane protein-1 oncogene deletions in nasal T-lymphocyte/natural killer cell lymphomas from Mexico

Mod Pathol. 1998 Aug;11(8):754-61.

Abstract

Nasal T-lymphocyte/natural killer cell lymphomas (nT/NKLs) are a distinct group of neoplasms highly associated with Epstein-Barr virus (EBV), with a high prevalence in Asia but rare in Western countries. Recent studies indicate that these neoplasms are of cytotoxic T- or NK-cell derivation. Previous studies identifying a characteristic 30-base pair deletion within the 3' end of latent membrane protein-1 (del-LMP-1) in other EBV-associated lymphomas suggested a pathogenetic role for del-LMP-1 in those neoplasms. We examined 23 cases of nT/NKL from Mexico for expression of the cytolytic granular proteins TIA-1 and perforin (PRF), and for the presence of EBV by in situ hybridization (ISH). Polymerase chain reaction was performed to identify the EBV (EBNA-2) strain type and the status of the LMP-1 gene (del-LMP-1). Controls consisted of 11 sinonasal B-cell lymphomas (nBLs) and 30 reactive tonsils (RTs) from healthy Mexican individuals. The nT/NKLs expressed TIA-1 in 21 (91%) of 23 cases and PRF in 15 (65%) of 23 cases. In contrast, all of the nBLs were negative for TIA-1 and PRF. Twenty-two (96%) of 23 nT/NKLs were positive for EBV by ISH. In contrast, only 2 (18%) of 11 nBLs were positive for EBV by ISH. EBV strain Type A was identified in 21 (91%) of 23 cases, whereas strain Type B was present in 2 (9%) of the 23 nT/NKLs. A similar percentage (80%) of Type A was noted in 12 of the 15 RTs. del-LMP-1 was detected in 6 (26%) of 23 nT/NKLs, comprising 4 cases of Type A and 2 of Type B. del-LMP-1 was detected in 9 (45%) of 20 RTs. Our results indicated that TIA-1 and PRF were sensitive markers of nT/NKL. The presence of del-LMP-1 in comparable frequencies in the RTs and nT/NKLs suggested to us that this genotype was common in the Mexican population and argued against a definite pathogenetic role for del-LMP-1 in nT/NKL.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Female
  • Gene Deletion*
  • Herpesvirus 4, Human / genetics*
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Killer Cells, Natural / pathology
  • Lymphoma, T-Cell / genetics
  • Lymphoma, T-Cell / metabolism*
  • Lymphoma, T-Cell / pathology
  • Lymphoma, T-Cell / virology
  • Male
  • Membrane Glycoproteins / metabolism*
  • Membrane Proteins / metabolism*
  • Mexico
  • Middle Aged
  • Nose Neoplasms / genetics
  • Nose Neoplasms / metabolism*
  • Nose Neoplasms / virology
  • Perforin
  • Poly(A)-Binding Proteins
  • Polymerase Chain Reaction
  • Pore Forming Cytotoxic Proteins
  • Proteins*
  • RNA-Binding Proteins / metabolism*
  • T-Cell Intracellular Antigen-1
  • Viral Matrix Proteins / genetics*

Substances

  • EBV-associated membrane antigen, Epstein-Barr virus
  • Membrane Glycoproteins
  • Membrane Proteins
  • Poly(A)-Binding Proteins
  • Pore Forming Cytotoxic Proteins
  • Proteins
  • RNA-Binding Proteins
  • T-Cell Intracellular Antigen-1
  • TIA1 protein, human
  • Viral Matrix Proteins
  • Perforin