Cyclic nucleotide-gated channels--mediators of NO:cGMP-regulated processes

M Biel; A Sautter; A Ludwig; F Hofmann; X Zong

doi:10.1007/pl00005235

Cyclic nucleotide-gated channels--mediators of NO:cGMP-regulated processes

Naunyn Schmiedebergs Arch Pharmacol. 1998 Jul;358(1):140-4. doi: 10.1007/pl00005235.

Authors

M Biel¹, A Sautter, A Ludwig, F Hofmann, X Zong

Affiliation

¹ Institut für Pharmakologie und Toxikologie der Technischen Universität München, Munich, Germany.

PMID: 9721016
DOI: 10.1007/pl00005235

Abstract

Cyclic nucleotide-gated (CNG) channels represent one of the three known cellular receptor classes for cGMP. Activation of CNG channels by binding of cyclic nucleotides to a site in the C-terminus results in opening of the channel pore, entry of Ca2+ into the cell and subsequent induction of Ca2+-dependent processes. In this review we will summarize new data on the complex molecular structure and the activation mechanism of CNG channels. In addition, we will discuss the role of CNG channels as mediators of NO:cGMP-dependent cellular processes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cyclic AMP / physiology*
Cyclic GMP / physiology*
Humans
Ion Channel Gating*
Ion Channels / chemistry
Nitric Oxide / physiology*

Substances

Ion Channels
Nitric Oxide
Cyclic AMP
Cyclic GMP