Abstract
Vaccination with DNA and recombinant vaccinia viruses (rec.VV) has been studied with the coxsackievirus B3 (CVB3) model system. Plasmids encoding all structural proteins of CVB3, when injected intramuscularly, induced only low levels of virus-specific antibodies. However, DNA vaccination with the major structural protein VP1 protected 72.2% of mice from lethal challenge, whereas VP1 expressed by rec.VV was much less efficient.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Viral / biosynthesis
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Antibodies, Viral / blood
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Coxsackievirus Infections / prevention & control*
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Coxsackievirus Infections / virology
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Enterovirus B, Human / genetics*
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Enterovirus B, Human / immunology
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Enterovirus B, Human / isolation & purification
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Enzyme-Linked Immunosorbent Assay
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Mice
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Mice, Inbred BALB C
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Plasmids
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Vaccines, DNA / administration & dosage
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Vaccines, DNA / therapeutic use*
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Vaccinia virus / genetics
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Viral Structural Proteins / genetics
Substances
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Antibodies, Viral
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Vaccines, DNA
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Viral Structural Proteins