[Endogenous retroviral sequences analogous to that of the new retrovirus MSRV associated with multiple sclerosis (part 1)]

C R Acad Sci III. 1998 Jun;321(6):495-9. doi: 10.1016/s0764-4469(98)80781-6.
[Article in French]

Abstract

Multiple sclerosis (MS) is still of unknown origin and may involve autoimmune, genetic and viral components in a pathogenic sequence whose relative importance is yet to be determined. A peptide, isolated from the cerebrospinal fluid of MS patients, is similar to a fragment of the pol protein reverse transcriptase (RT) of the newly reported MSRV retrovirus. The 700 amino acid sequence of MSRV-RT is closely related to a novel human retroviral-like sequences. We also identified a gag-like sequence upstream of this human genomic RT-like sequence, which allowed us to identify altogether 4,000 nucleotides, possibly coding for an endogenous retroviruses. Homologous sequences found in other locations in the human genome seem to characterize a new family of retroviral endogenous sequences, which may be of relevance to multiple sclerosis.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Endogenous Retroviruses / genetics*
  • Genome, Human*
  • Humans
  • Molecular Sequence Data
  • Multiple Sclerosis / genetics*
  • RNA-Directed DNA Polymerase / genetics
  • Ribonuclease H / genetics
  • Sequence Homology, Amino Acid

Substances

  • RNA-Directed DNA Polymerase
  • Ribonuclease H