[The energy parameters of the liver mitochondria under the prolonged action of halothane in vitro]

I V Ovchinnikov; N P Kim; R N Akhmerov; G F Ishankulova

[The energy parameters of the liver mitochondria under the prolonged action of halothane in vitro]

Eksp Klin Farmakol. 1998 Jul-Aug;61(4):38-40.

[Article in Russian]

Authors

I V Ovchinnikov¹, N P Kim, R N Akhmerov, G F Ishankulova

Affiliation

¹ Laboratory of Biochemistry, Uzbekistan Republic Ministry of Public Health, Tashkent.

PMID: 9783107

Abstract

The effect of 10-, 30-, 60-, 90-, and 120-min exposure to halotane vapors on the energy parameters of mitochondria of the liver of albino rats was studied in in vitro experiments. In long-term contact of the mitochondria with halotane the respiratory and phosphorylation function of the mitochondria in oxidation of PAD- and NAD-dependent substrates was disturbed.

Publication types

Comparative Study
English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Anesthetics, Inhalation / pharmacology*
Animals
Energy Metabolism / drug effects*
Halothane / pharmacology*
In Vitro Techniques
Mitochondria, Liver / drug effects*
Mitochondria, Liver / metabolism
Oxidative Phosphorylation / drug effects
Rats
Time Factors

Substances

Anesthetics, Inhalation
Halothane