Metastatic granulosa-cell tumor in the liver: cytopathologic findings and staining with inhibin

Diagn Cytopathol. 1998 Oct;19(4):293-7. doi: 10.1002/(sici)1097-0339(199810)19:4<293::aid-dc14>3.0.co;2-i.

Abstract

Adult granulosa-cell tumor (AGCT) is an uncommon ovarian malignancy. Rarely, hepatic metastasis of this tumor may present a difficult cytologic diagnosis when such a lesion is aspirated. This case report elaborates the cytopathologic features of AGCT in the liver aspirate of a 60-yr-old woman. Correlation with histopathology and intraoperative touch-imprint cytology of the subsequent hepatic resection is also presented. The role of immunoperoxidase studies especially utilizing inhibin is also highlighted.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biopsy, Needle
  • Cell Nucleus / pathology
  • Cytoplasm / pathology
  • Female
  • Granulosa Cell Tumor / diagnosis
  • Granulosa Cell Tumor / pathology
  • Granulosa Cell Tumor / secondary*
  • Humans
  • Immunoenzyme Techniques
  • Inhibins / analysis*
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / pathology
  • Liver Neoplasms / secondary*
  • Ovarian Neoplasms / pathology*
  • Specimen Handling

Substances

  • Inhibins