Polymorphism of TAPASIN and its linkage disequilibria with HLA class II genes in the Japanese population

Tissue Antigens. 1998 Sep;52(3):279-81. doi: 10.1111/j.1399-0039.1998.tb03044.x.

Abstract

Tapasin plays an important role in HLA class I assembly. The gene has been mapped on the human MHC region. We identified two alleles of TAPASIN in the Japanese population and analyzed the association of the alleles with HLA-DPB1, -DQB1 and -DRB1 alleles. The allele frequencies of TAPASIN*01 and *02 were estimated to be 0.37 and 0.63, respectively, in the Japanese population. TAPASIN showed strong linkage disequilibrium with the HLA-DPB1 locus. Several frequent four-locus haplotypes were identified, including DRB1*0901-DQB1*0303-DPB1*0501-TAPASIN*02, DRB1*0901-DQB1*0303-DPB1*0201-TAPASIN*02 and DRB1*1302-DQB1*0604-DPB1*0401-TAPASIN*02.

MeSH terms

  • Antiporters / genetics*
  • Asian People / genetics*
  • HLA Antigens / genetics*
  • Histocompatibility Antigens Class I / genetics*
  • Histocompatibility Antigens Class II / genetics*
  • Humans
  • Immunoglobulins / genetics*
  • Japan / epidemiology
  • Linkage Disequilibrium / genetics*
  • Membrane Transport Proteins
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polymorphism, Genetic / genetics*
  • Polymorphism, Restriction Fragment Length
  • Random Allocation

Substances

  • Antiporters
  • HLA Antigens
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • Immunoglobulins
  • Membrane Transport Proteins
  • tapasin

Associated data

  • GENBANK/AB010639
  • GENBANK/AB012622
  • GENBANK/AB012920