Abstract
Tapasin plays an important role in HLA class I assembly. The gene has been mapped on the human MHC region. We identified two alleles of TAPASIN in the Japanese population and analyzed the association of the alleles with HLA-DPB1, -DQB1 and -DRB1 alleles. The allele frequencies of TAPASIN*01 and *02 were estimated to be 0.37 and 0.63, respectively, in the Japanese population. TAPASIN showed strong linkage disequilibrium with the HLA-DPB1 locus. Several frequent four-locus haplotypes were identified, including DRB1*0901-DQB1*0303-DPB1*0501-TAPASIN*02, DRB1*0901-DQB1*0303-DPB1*0201-TAPASIN*02 and DRB1*1302-DQB1*0604-DPB1*0401-TAPASIN*02.
MeSH terms
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Antiporters / genetics*
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Asian People / genetics*
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HLA Antigens / genetics*
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Histocompatibility Antigens Class I / genetics*
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Histocompatibility Antigens Class II / genetics*
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Humans
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Immunoglobulins / genetics*
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Japan / epidemiology
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Linkage Disequilibrium / genetics*
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Membrane Transport Proteins
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Molecular Sequence Data
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Polymerase Chain Reaction
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Polymorphism, Genetic / genetics*
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Polymorphism, Restriction Fragment Length
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Random Allocation
Substances
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Antiporters
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HLA Antigens
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Histocompatibility Antigens Class I
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Histocompatibility Antigens Class II
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Immunoglobulins
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Membrane Transport Proteins
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tapasin
Associated data
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GENBANK/AB010639
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GENBANK/AB012622
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GENBANK/AB012920