Reversible parkinsonism induced by prolonged treatment with valproate

J Neurol. 1998 Dec;245(12):794-6. doi: 10.1007/s004150050288.

Abstract

We describe two patients who developed levodopa-responsive parkinsonism without dementia at least 4 years after beginning chronic valproate (VPA) treatment for seizures. Parkinsonism disappeared in less than 3 months after VPA substitution with carbamazepine.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anticonvulsants / adverse effects*
  • Antiparkinson Agents / therapeutic use
  • Carbidopa / therapeutic use
  • Female
  • Humans
  • Levodopa / therapeutic use
  • Male
  • Middle Aged
  • Parkinson Disease, Secondary / chemically induced*
  • Parkinson Disease, Secondary / drug therapy
  • Remission Induction
  • Seizures / prevention & control
  • Valproic Acid / adverse effects*

Substances

  • Anticonvulsants
  • Antiparkinson Agents
  • Levodopa
  • Valproic Acid
  • Carbidopa