Abstract
A series of C-terminus capped dipeptides and tripeptides was synthesized as growth hormone (GH) secretagogues. Among them, tripeptide Aib-D-Trp-D-homoPhe-OEt showed low nanomolar activity in the rat pituitary assay. Thus, we have demonstrated that the GH secretagogue activity of the hexa-hepta-GH releasing peptides can be mimicked at the tripeptide level.
MeSH terms
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Amino Acid Sequence
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Animals
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Dipeptides / chemical synthesis*
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Dipeptides / chemistry
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Dipeptides / pharmacology
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Growth Hormone / metabolism*
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In Vitro Techniques
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Models, Molecular
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Molecular Structure
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Oligopeptides / chemical synthesis*
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Oligopeptides / chemistry
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Oligopeptides / pharmacology
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Pituitary Gland / metabolism
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Rats
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Structure-Activity Relationship
Substances
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Dipeptides
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Oligopeptides
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alanyl-histidyl-(2-naphthyl)alanyl-tryptophyl-phenylalanyl-lysinamide
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growth hormone releasing hexapeptide
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Growth Hormone
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growth hormone-releasing peptide-2