Tripeptide growth hormone secretagogues

Bioorg Med Chem Lett. 1998 Apr 7;8(7):759-64. doi: 10.1016/s0960-894x(98)00103-6.

Abstract

A series of C-terminus capped dipeptides and tripeptides was synthesized as growth hormone (GH) secretagogues. Among them, tripeptide Aib-D-Trp-D-homoPhe-OEt showed low nanomolar activity in the rat pituitary assay. Thus, we have demonstrated that the GH secretagogue activity of the hexa-hepta-GH releasing peptides can be mimicked at the tripeptide level.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Dipeptides / chemical synthesis*
  • Dipeptides / chemistry
  • Dipeptides / pharmacology
  • Growth Hormone / metabolism*
  • In Vitro Techniques
  • Models, Molecular
  • Molecular Structure
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / chemistry
  • Oligopeptides / pharmacology
  • Pituitary Gland / metabolism
  • Rats
  • Structure-Activity Relationship

Substances

  • Dipeptides
  • Oligopeptides
  • alanyl-histidyl-(2-naphthyl)alanyl-tryptophyl-phenylalanyl-lysinamide
  • growth hormone releasing hexapeptide
  • Growth Hormone
  • growth hormone-releasing peptide-2