Abstract
Carbocyclic analogues of the antibacterial natural product frenolicin B have been synthesised. These analogues were active against parasitic protozoa of the genus Eimeria and represent a new series of anticoccidial agents. The synthesis of simplified analogues helped to define a possible pharmacophore for frenolicin.
MeSH terms
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Animals
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Antiprotozoal Agents / chemical synthesis
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Antiprotozoal Agents / chemistry*
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Antiprotozoal Agents / pharmacology
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Antiprotozoal Agents / therapeutic use
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Coccidiosis / drug therapy*
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Eimeria / drug effects
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Naphthoquinones / chemical synthesis
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Naphthoquinones / chemistry
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Naphthoquinones / pharmacology
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Naphthoquinones / therapeutic use
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Antiprotozoal Agents
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Naphthoquinones
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frenolicin B