Synthesis and in vitro cytotoxicity of C(20)(RS)-camptothecin analogues modified at both B (or A) and E ring

S S Jew; M G Kim; H J Kim; E Y Rho; H G Park; J K Kim; H J Han; H Lee

doi:10.1016/s0960-894x(98)00317-5

Synthesis and in vitro cytotoxicity of C(20)(RS)-camptothecin analogues modified at both B (or A) and E ring

Bioorg Med Chem Lett. 1998 Jul 21;8(14):1797-800. doi: 10.1016/s0960-894x(98)00317-5.

Authors

S S Jew¹, M G Kim, H J Kim, E Y Rho, H G Park, J K Kim, H J Han, H Lee

Affiliation

¹ College of Pharmacy, Seoul National University, Korea.

PMID: 9873436
DOI: 10.1016/s0960-894x(98)00317-5

Abstract

A series of C(7) and C(20)-substituted camptothecin derivatives (12-14, 16-18) are prepared. Their syntheses and in vitro cytotoxicities are reported.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology*
Camptothecin / analogs & derivatives*
Camptothecin / chemical synthesis*
Camptothecin / pharmacology
Humans
Structure-Activity Relationship
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Camptothecin