SAR of novel biarylmethylamine dopamine D4 receptor ligands

Bioorg Med Chem Lett. 1998 Aug 4;8(15):2033-8. doi: 10.1016/s0960-894x(98)00361-8.

Abstract

SAR for a novel series of dopamine D4 receptor ligands is shown. Very selective, highly potent compounds like 1-(2-pyrimidinyl)-4-(3-(3-thienyl)-benzyl)-piperazine (5f) and 2-(4-(1-fluorenylmethyl)-1-piperazinyl)-pyrimidine (8c) were obtained.

MeSH terms

  • Animals
  • Dopamine Antagonists / metabolism
  • Dopamine Antagonists / pharmacology
  • Ligands
  • Methylamines / chemistry*
  • Methylamines / metabolism
  • Methylamines / pharmacology
  • Mice
  • Receptors, Dopamine D2 / metabolism*
  • Receptors, Dopamine D4
  • Structure-Activity Relationship

Substances

  • Dopamine Antagonists
  • Drd4 protein, mouse
  • Ligands
  • Methylamines
  • Receptors, Dopamine D2
  • Receptors, Dopamine D4
  • methylamine