Synthesis and biological evaluation of a water soluble phosphate prodrug of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP)

Bioorg Med Chem Lett. 1998 Nov 17;8(22):3159-64. doi: 10.1016/s0960-894x(98)00573-3.

Abstract

With the aim of improving its biological and pharmaceutical profiles, two water soluble phosphate prodrugs of 3-AP, 3a and 3b were prepared. The detailed synthesis and the preliminary evaluation of these prodrugs are described.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Dogs
  • Drug Stability
  • Mice
  • Mice, Inbred BALB C
  • Prodrugs / chemical synthesis*
  • Prodrugs / pharmacology
  • Pyridines / chemical synthesis*
  • Pyridines / pharmacology
  • Solubility
  • Thiosemicarbazones / chemical synthesis*
  • Thiosemicarbazones / pharmacology

Substances

  • Antineoplastic Agents
  • Prodrugs
  • Pyridines
  • Thiosemicarbazones
  • 3-aminopyridine-2-carboxaldehyde thiosemicarbazone