[The search for new anti-ulcer agents from plants in Siberia and the Far East]

Eksp Klin Farmakol. 1998 Nov-Dec;61(6):31-5.
[Article in Russian]

Abstract

Screening tests on mice with the use of a model of neurogenic damage to the stomach revealed antiulcerative activity in extracts of Amoor cork tree, Pacific Bergenia, Lespedeza dichromatic, Leuzea carthamoides, sea-buckthorn, common aspen, Manchurian nuts, Serratula coronarius, and Scutellaria baicalensis. It was proved that an extract of aspen cork produces a marked antiulcerative effect on being administered to animals with "acute" ulcers and in treatment of chronic peptic ulcer. The study of various drug forms of Serratula coronarius extracts (prepared from the bark and the bark and shoots) in experiments on mice (neurogenic ulcer) and rats (Aspirin ulcer) revealed the most marked gastroprotective effect of oil extracts of bark and shoots. A high antiulcerogenic activity of extracts prepared from grass and roots of Scutellaria baicalensis was demonstrated.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anti-Ulcer Agents / therapeutic use*
  • Aspirin
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Mice
  • Plant Extracts / therapeutic use
  • Plants, Medicinal*
  • Rats
  • Restraint, Physical
  • Siberia
  • Stomach Ulcer / drug therapy
  • Stomach Ulcer / etiology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Anti-Ulcer Agents
  • Plant Extracts
  • Aspirin