Conservative surgery in Crohn's disease causes multiple enteral anastomoses. In 120 patients who underwent resectional surgery for Crohn's disease with a total of 165 anastomoses we analyzed the risk factors (a) number of anastomoses per operation, (b) preoperative cortisone, and (c) the resection margins in relation to the major postoperative complications. With a total of five major complications and no mortality we could not observe an increased risk for a higher morbidity in Crohn's disease surgery with multiple anastomoses.