Coprophilin: an anticoccidial agent produced by a dung inhabiting fungus

Bioorg Med Chem Lett. 1998 Dec 15;8(24):3439-42. doi: 10.1016/s0960-894x(98)00629-5.

Abstract

Coprophilin, a decalin pentanedienoic acid methyl ester, was isolated from an unidentified fungus by bioassay guided separation. It inhibited (MIC = 1.5 microM) the growth of Eimeria tenella in an in vitro assay. The isolation, structure elucidation, absolute stereochemistry and biology are described.

MeSH terms

  • Alkenes / chemical synthesis
  • Alkenes / chemistry
  • Alkenes / pharmacology*
  • Animals
  • Cattle
  • Cell Line
  • Coccidiostats / chemistry
  • Coccidiostats / pharmacology*
  • Eimeria tenella / drug effects*
  • Esters / chemical synthesis
  • Esters / chemistry
  • Esters / pharmacology*
  • Feces / microbiology
  • Fungi / metabolism*
  • Molecular Structure
  • Spectrometry, Mass, Fast Atom Bombardment
  • Stereoisomerism

Substances

  • Alkenes
  • Coccidiostats
  • Esters
  • coprophilin