[The effects of low-doses of fentanyl, buprenorphine and pentazocine on circulatory responses to endotracheal intubation]

Masui. 1998 Dec;47(12):1478-81.
[Article in Japanese]

Abstract

This study evaluates the effects of low-doses i.v. fentanyl, buprenorphine and pentazocine on circulatory responses of endotracheal intubation in 70 scheduled surgical patients. Patients were allocated to 5 groups randomly and 2 (n = 11) or 4 (n = 13) micrograms.kg-1 of fentanyl, 0.5 mg.kg-1 of pentazocine (n = 13), 5 micrograms.kg-1 of buprenorphine (n = 10) and saline as a control (n = 23) were administered 5 minutes before the administration of thiopental, respectively. Then, patients were intubated with 0.1 mg.kg-1 of vecuronium. Blood pressure and heart rate were recorded. Only 4 micrograms.kg-1 of fentanyl diminished circulatory responses of systolic blood pressure on the stimuli of endotracheal intubation.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adjuvants, Anesthesia / administration & dosage*
  • Adjuvants, Anesthesia / pharmacology
  • Blood Pressure* / drug effects
  • Buprenorphine / administration & dosage*
  • Buprenorphine / pharmacology
  • Female
  • Fentanyl / administration & dosage*
  • Fentanyl / pharmacology
  • Heart Rate* / drug effects
  • Humans
  • Infusions, Intravenous
  • Intubation, Intratracheal*
  • Male
  • Pentazocine / administration & dosage*
  • Pentazocine / pharmacology

Substances

  • Adjuvants, Anesthesia
  • Buprenorphine
  • Pentazocine
  • Fentanyl