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A typical bacterial ornithine-containing lipid Nalpha-(D)-[3-(hexadecanoyloxy)hexadecanoyl]-ornithine is a strong stimulant for macrophages and a useful adjuvant.
Kawai Y, Nakagawa Y, Matuyama T, Akagawa K, Itagawa K, Fukase K, Kusumoto S, Nishijima M, Yano I. Kawai Y, et al. Among authors: kusumoto s. FEMS Immunol Med Microbiol. 1999 Jan;23(1):67-73. doi: 10.1111/j.1574-695X.1999.tb01718.x. FEMS Immunol Med Microbiol. 1999. PMID: 10030549 Free article.
Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization.
Saitoh S, Akashi S, Yamada T, Tanimura N, Kobayashi M, Konno K, Matsumoto F, Fukase K, Kusumoto S, Nagai Y, Kusumoto Y, Kosugi A, Miyake K. Saitoh S, et al. Among authors: kusumoto s, kusumoto y. Int Immunol. 2004 Jul;16(7):961-9. doi: 10.1093/intimm/dxh097. Epub 2004 Jun 7. Int Immunol. 2004. PMID: 15184344
Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture.
Uehara A, Yang S, Fujimoto Y, Fukase K, Kusumoto S, Shibata K, Sugawara S, Takada H. Uehara A, et al. Among authors: kusumoto s. Cell Microbiol. 2005 Jan;7(1):53-61. doi: 10.1111/j.1462-5822.2004.00433.x. Cell Microbiol. 2005. PMID: 15617523
Key structures of bacterial peptidoglycan and lipopolysaccharide triggering the innate immune system of higher animals: chemical synthesis and functional studies.
Kusumoto S, Fukase K, Shiba T. Kusumoto S, et al. Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(4):322-37. doi: 10.2183/pjab.86.322. Proc Jpn Acad Ser B Phys Biol Sci. 2010. Corrected and republished in: Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(5):322-37. PMID: 20431259 Free PMC article. Corrected and republished. Review.
569 results