Bethell RC - Search Results

1

Sialidase inhibitors related to zanamivir: synthesis and biological evaluation of 4H-pyran 6-ether and ketone.

Smith PW, Robinson JE, Evans DN, Sollis SL, Howes PD, Trivedi N, Bethell RC. Smith PW, et al. Among authors: bethell rc. Bioorg Med Chem Lett. 1999 Feb 22;9(4):601-4. doi: 10.1016/s0960-894x(99)00031-1. Bioorg Med Chem Lett. 1999. PMID: 10098672

2

Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.

Smith PW, Sollis SL, Howes PD, Cherry PC, Starkey ID, Cobley KN, Weston H, Scicinski J, Merritt A, Whittington A, Wyatt P, Taylor N, Green D, Bethell R, Madar S, Fenton RJ, Morley PJ, Pateman T, Beresford A. Smith PW, et al. J Med Chem. 1998 Mar 12;41(6):787-97. doi: 10.1021/jm970374b. J Med Chem. 1998. PMID: 9526555

3

Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.

Taylor NR, Cleasby A, Singh O, Skarzynski T, Wonacott AJ, Smith PW, Sollis SL, Howes PD, Cherry PC, Bethell R, Colman P, Varghese J. Taylor NR, et al. J Med Chem. 1998 Mar 12;41(6):798-807. doi: 10.1021/jm9703754. J Med Chem. 1998. PMID: 9526556

4

Synthesis of tetrasubstituted bicyclo[3.2.1]octenes as potential inhibitors of influenza virus sialidase.

Jones PS, Smith PW, Hardy GW, Howes PD, Upton RJ, Bethell RC. Jones PS, et al. Among authors: bethell rc. Bioorg Med Chem Lett. 1999 Feb 22;9(4):605-10. doi: 10.1016/s0960-894x(99)00032-3. Bioorg Med Chem Lett. 1999. PMID: 10098673

5

Synthesis of a tetrasubstituted bicyclo [2.2.2] octane as a potential inhibitor of influenza virus sialidase.

Smith PW, Trivedi N, Howes PD, Sollis SL, Rahim G, Bethell RC, Lynn S. Smith PW, et al. Among authors: bethell rc. Bioorg Med Chem Lett. 1999 Feb 22;9(4):611-4. doi: 10.1016/s0960-894x(99)00033-5. Bioorg Med Chem Lett. 1999. PMID: 10098674

6

Benzophenone derivatives: a novel series of potent and selective inhibitors of human immunodeficiency virus type 1 reverse transcriptase.

Wyatt PG, Bethell RC, Cammack N, Charon D, Dodic N, Dumaitre B, Evans DN, Green DV, Hopewell PL, Humber DC, et al. Wyatt PG, et al. Among authors: bethell rc. J Med Chem. 1995 May 12;38(10):1657-65. doi: 10.1021/jm00010a010. J Med Chem. 1995. PMID: 7538590

7

Sialidase as a target for inhibitors of influenza virus replication.

Bethell RC, Smith PW. Bethell RC, et al. Expert Opin Investig Drugs. 1997 Oct;6(10):1501-9. doi: 10.1517/13543784.6.10.1501. Expert Opin Investig Drugs. 1997. PMID: 15989515

8

A series of penicillin derived C2-symmetric inhibitors of HIV-1 proteinase: synthesis, mode of interaction, and structure-activity relationships.

Humber DC, Bamford MJ, Bethell RC, Cammack N, Cobley K, Evans DN, Gray NM, Hann MM, Orr DC, Saunders J, et al. Humber DC, et al. Among authors: bethell rc. J Med Chem. 1993 Oct 15;36(21):3120-8. doi: 10.1021/jm00073a011. J Med Chem. 1993. PMID: 8230098

9

Synthesis and structure-activity relationships of a series of penicillin-derived HIV proteinase inhibitors: heterocyclic ring systems containing P1' and P2' substituents.

Kitchin J, Bethell RC, Cammack N, Dolan S, Evans DN, Holman S, Holmes DS, McMeekin P, Mo CL, Nieland N, et al. Kitchin J, et al. Among authors: bethell rc. J Med Chem. 1994 Oct 28;37(22):3707-16. doi: 10.1021/jm00048a007. J Med Chem. 1994. PMID: 7966131

10

Biaryl acids: novel non-nucleoside inhibitors of HIV reverse transcriptase types 1 and 2.

Milton J, Slater MJ, Bird AJ, Spinks D, Scott G, Price CE, Downing S, Green DV, Madar S, Bethell R, Stammers DK. Milton J, et al. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2623-8. doi: 10.1016/s0960-894x(98)00214-5. Bioorg Med Chem Lett. 1998. PMID: 9873592 Review.

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