Structural basis for the resistance of Tay-Sachs ganglioside GM2 to enzymatic degradation.
Li YT, Li SC, Hasegawa A, Ishida H, Kiso M, Bernardi A, Brocca P, Raimondi L, Sonnino S.
Li YT, et al. Among authors: kiso m.
J Biol Chem. 1999 Apr 9;274(15):10014-8. doi: 10.1074/jbc.274.15.10014.
J Biol Chem. 1999.
PMID: 10187778
Free article.
While GM2 has GalNAcbeta1-->4Gal linkage, 6'-GM2 has GalNAcbeta1-->6Gal linkage (Ishida, H., Ito, Y., Tanahashi, E., Li, Y.-T., Kiso, M., and Hasegawa, A. (1997) Carbohydr. Res. 302, 223-227). We have studied the enzymatic susceptibilities of GM2 and 6'GM2, as …
While GM2 has GalNAcbeta1-->4Gal linkage, 6'-GM2 has GalNAcbeta1-->6Gal linkage (Ishida, H., Ito, Y., Tanahashi, E., Li, Y.-T., Kis …