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The design and synthesis of thrombin inhibitors: analogues of MD805 containing non-polar surrogates for arginine at the P1 position.
Baettig U, Brown L, Brundish D, Dell C, Furzer A, Garman S, Janus D, Kane PD, Smith G, Walker CV, Cockcroft X, Ambler J, Mitchelson A, Talbot MD, Tweed M, Wills N. Baettig U, et al. Among authors: kane pd. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1563-6. doi: 10.1016/s0960-894x(00)00282-1. Bioorg Med Chem Lett. 2000. PMID: 10915051
The design and synthesis of thrombin inhibitors: the introduction of in vivo efficacy and oral bioavailability into benzthiazolylalanine inhibitors.
Hayler J, Kane PD, LeGrand D, Lugrin F, Menear K, Price R, Allen M, Cockcroft X, Ambler J, Butler K, Dunnet K, Mitchelson A, Talbot M, Tweed M, Wills N. Hayler J, et al. Among authors: kane pd. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1567-70. doi: 10.1016/s0960-894x(00)00283-3. Bioorg Med Chem Lett. 2000. PMID: 10915052
488 results