Schaeffer CA - Search Results

1

Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency.

Cushman M, Insaf S, Paul G, Ruell JA, De Clercq E, Schols D, Pannecouque C, Witvrouw M, Schaeffer CA, Turpin JA, Williamson K, Rice WG. Cushman M, et al. Among authors: schaeffer ca. J Med Chem. 1999 May 20;42(10):1767-77. doi: 10.1021/jm980727m. J Med Chem. 1999. PMID: 10346929

2

New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors.

Cushman M, Casimiro-Garcia A, Hejchman E, Ruell JA, Huang M, Schaeffer CA, Williamson K, Rice WG, Buckheit RW Jr. Cushman M, et al. Among authors: schaeffer ca. J Med Chem. 1998 Jun 4;41(12):2076-89. doi: 10.1021/jm9800595. J Med Chem. 1998. PMID: 9622549

3

Synthesis of a cosalane analog with an extended polyanionic pharmacophore conferring enhanced potency as an anti-HIV agent.

Cushman M, Insaf S, Ruell JA, Schaeffer CA, Rice WG. Cushman M, et al. Among authors: schaeffer ca. Bioorg Med Chem Lett. 1998 Apr 7;8(7):833-6. doi: 10.1016/s0960-894x(98)00121-8. Bioorg Med Chem Lett. 1998. PMID: 9871550

4

Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.

Rice WG, Turpin JA, Schaeffer CA, Graham L, Clanton D, Buckheit RW Jr, Zaharevitz D, Summers MF, Wallqvist A, Covell DG. Rice WG, et al. Among authors: schaeffer ca. J Med Chem. 1996 Sep 13;39(19):3606-16. doi: 10.1021/jm960375o. J Med Chem. 1996. PMID: 8809151

5

All-atom models for the non-nucleoside binding site of HIV-1 reverse transcriptase complexed with inhibitors: a 3D QSAR approach.

Gussio R, Pattabiraman N, Zaharevitz DW, Kellogg GE, Topol IA, Rice WG, Schaeffer CA, Erickson JW, Burt SK. Gussio R, et al. Among authors: schaeffer ca. J Med Chem. 1996 Apr 12;39(8):1645-50. doi: 10.1021/jm9508088. J Med Chem. 1996. PMID: 8648604

6

Inhibition of acute-, latent-, and chronic-phase human immunodeficiency virus type 1 (HIV-1) replication by a bistriazoloacridone analog that selectively inhibits HIV-1 transcription.

Turpin JA, Buckheit RW Jr, Derse D, Hollingshead M, Williamson K, Palamone C, Osterling MC, Hill SA, Graham L, Schaeffer CA, Bu M, Huang M, Cholody WM, Michejda CJ, Rice WG. Turpin JA, et al. Among authors: schaeffer ca. Antimicrob Agents Chemother. 1998 Mar;42(3):487-94. doi: 10.1128/AAC.42.3.487. Antimicrob Agents Chemother. 1998. PMID: 9517921 Free PMC article.

7

Human immunodeficiency virus type-1 (HIV-1) replication is unaffected by human secretory leukocyte protease inhibitor.

Turpin JA, Schaeffer CA, Bu M, Graham L, Buckheit RW Jr, Clanton D, Rice WG. Turpin JA, et al. Among authors: schaeffer ca. Antiviral Res. 1996 Mar;29(2-3):269-77. doi: 10.1016/0166-3542(95)00907-8. Antiviral Res. 1996. PMID: 8739605

8

Inhibition of multiple phases of human immunodeficiency virus type 1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins.

Rice WG, Baker DC, Schaeffer CA, Graham L, Bu M, Terpening S, Clanton D, Schultz R, Bader JP, Buckheit RW Jr, Field L, Singh PK, Turpin JA. Rice WG, et al. Among authors: schaeffer ca. Antimicrob Agents Chemother. 1997 Feb;41(2):419-26. doi: 10.1128/AAC.41.2.419. Antimicrob Agents Chemother. 1997. PMID: 9021201 Free PMC article.

9

Inhibitors of human immunodeficiency virus type 1 zinc fingers prevent normal processing of gag precursors and result in the release of noninfectious virus particles.

Turpin JA, Terpening SJ, Schaeffer CA, Yu G, Glover CJ, Felsted RL, Sausville EA, Rice WG. Turpin JA, et al. Among authors: schaeffer ca. J Virol. 1996 Sep;70(9):6180-9. doi: 10.1128/JVI.70.9.6180-6189.1996. J Virol. 1996. PMID: 8709244 Free PMC article.

10

Inhibitors of HIV nucleocapsid protein zinc fingers as candidates for the treatment of AIDS.

Rice WG, Supko JG, Malspeis L, Buckheit RW Jr, Clanton D, Bu M, Graham L, Schaeffer CA, Turpin JA, Domagala J, Gogliotti R, Bader JP, Halliday SM, Coren L, Sowder RC 2nd, Arthur LO, Henderson LE. Rice WG, et al. Among authors: schaeffer ca. Science. 1995 Nov 17;270(5239):1194-7. doi: 10.1126/science.270.5239.1194. Science. 1995. PMID: 7502043

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