Helk B - Search Results

1

Utility of isotachophoresis-capillary zone electrophoresis, mass spectrometry and high-performance size-exclusion chromatography for monitoring of interleukin-6 dimer formation.

Gysler J, Mazereeuw M, Helk B, Heitzmann M, Jaehde U, Schunack W, Tjaden UR, van der Greef J. Gysler J, et al. Among authors: helk b. J Chromatogr A. 1999 May 7;841(1):63-73. doi: 10.1016/s0021-9673(99)00257-5. J Chromatogr A. 1999. PMID: 10360328

2

Characterization of recombinant cytokine fragments using isotachophoresis-capillary zone electrophoresis, reversed-phase high performance liquid chromatography, and mass spectrometry.

Gysler J, Helk B, Dambacher S, Tjaden UR, van der Greef J. Gysler J, et al. Among authors: helk b. Pharm Res. 1999 May;16(5):695-701. doi: 10.1023/a:1018824608288. Pharm Res. 1999. PMID: 10350013

3

Structure-activity relationship for hydrophobic salts as viscosity-lowering excipients for concentrated solutions of monoclonal antibodies.

Guo Z, Chen A, Nassar RA, Helk B, Mueller C, Tang Y, Gupta K, Klibanov AM. Guo Z, et al. Among authors: helk b. Pharm Res. 2012 Nov;29(11):3102-9. doi: 10.1007/s11095-012-0802-9. Epub 2012 Jun 13. Pharm Res. 2012. PMID: 22692671

4

Evaluation of a non-Arrhenius model for therapeutic monoclonal antibody aggregation.

Kayser V, Chennamsetty N, Voynov V, Helk B, Forrer K, Trout BL. Kayser V, et al. Among authors: helk b. J Pharm Sci. 2011 Jul;100(7):2526-42. doi: 10.1002/jps.22493. Epub 2011 Jan 25. J Pharm Sci. 2011. PMID: 21268027

5

Glycosylation influences on the aggregation propensity of therapeutic monoclonal antibodies.

Kayser V, Chennamsetty N, Voynov V, Forrer K, Helk B, Trout BL. Kayser V, et al. Among authors: helk b. Biotechnol J. 2011 Jan;6(1):38-44. doi: 10.1002/biot.201000091. Biotechnol J. 2011. PMID: 20949542

6

Conformational stability and aggregation of therapeutic monoclonal antibodies studied with ANS and Thioflavin T binding.

Kayser V, Chennamsetty N, Voynov V, Helk B, Trout BL. Kayser V, et al. Among authors: helk b. MAbs. 2011 Jul-Aug;3(4):408-11. doi: 10.4161/mabs.3.4.15677. Epub 2011 Jul 1. MAbs. 2011. PMID: 21540645 Free PMC article.

7

Aggregation in protein-based biotherapeutics: computational studies and tools to identify aggregation-prone regions.

Agrawal NJ, Kumar S, Wang X, Helk B, Singh SK, Trout BL. Agrawal NJ, et al. Among authors: helk b. J Pharm Sci. 2011 Dec;100(12):5081-95. doi: 10.1002/jps.22705. Epub 2011 Jul 24. J Pharm Sci. 2011. PMID: 21789769 Review.

8

Developability index: a rapid in silico tool for the screening of antibody aggregation propensity.

Lauer TM, Agrawal NJ, Chennamsetty N, Egodage K, Helk B, Trout BL. Lauer TM, et al. Among authors: helk b. J Pharm Sci. 2012 Jan;101(1):102-15. doi: 10.1002/jps.22758. Epub 2011 Sep 20. J Pharm Sci. 2012. PMID: 21935950

9

A screening tool for therapeutic monoclonal antibodies: Identifying the most stable protein and its best formulation based on thioflavin T binding.

Kayser V, Chennamsetty N, Voynov V, Helk B, Forrer K, Trout BL. Kayser V, et al. Among authors: helk b. Biotechnol J. 2012 Jan;7(1):127-32. doi: 10.1002/biot.201100366. Epub 2011 Nov 21. Biotechnol J. 2012. PMID: 21953825

10

Design of therapeutic proteins with enhanced stability.

Chennamsetty N, Voynov V, Kayser V, Helk B, Trout BL. Chennamsetty N, et al. Among authors: helk b. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11937-42. doi: 10.1073/pnas.0904191106. Epub 2009 Jul 1. Proc Natl Acad Sci U S A. 2009. PMID: 19571001 Free PMC article.

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