de Haard HJ - Search Results

1

A large non-immunized human Fab fragment phage library that permits rapid isolation and kinetic analysis of high affinity antibodies.

de Haard HJ, van Neer N, Reurs A, Hufton SE, Roovers RC, Henderikx P, de Bruïne AP, Arends JW, Hoogenboom HR. de Haard HJ, et al. Among authors: de bruine ap. J Biol Chem. 1999 Jun 25;274(26):18218-30. doi: 10.1074/jbc.274.26.18218. J Biol Chem. 1999. PMID: 10373423 Free article.

2

Selection of recombinant, library-derived antibody fragments against p24 for human immunodeficiency virus type 1 diagnostics.

de Haard HJ, Kazemier B, Koolen MJ, Nijholt LJ, Meloen RH, van Gemen B, Hoogenboom HR, Arends JW. de Haard HJ, et al. Clin Diagn Lab Immunol. 1998 Sep;5(5):636-44. doi: 10.1128/CDLI.5.5.636-644.1998. Clin Diagn Lab Immunol. 1998. PMID: 9729530 Free PMC article.

3

Absolute conservation of residue 6 of immunoglobulin heavy chain variable regions of class IIA is required for correct folding.

de Haard HJ, Kazemier B, van der Bent A, Oudshoorn P, Boender P, van Gemen B, Arends JW, Hoogenboom HR. de Haard HJ, et al. Protein Eng. 1998 Dec;11(12):1267-76. doi: 10.1093/protein/11.12.1267. Protein Eng. 1998. PMID: 9930677

4

Determination of active single chain antibody concentrations in crude periplasmic fractions.

Kazemier B, de Haard H, Boender P, van Gemen B, Hoogenboom H. Kazemier B, et al. J Immunol Methods. 1996 Aug 14;194(2):201-9. doi: 10.1016/0022-1759(96)00086-5. J Immunol Methods. 1996. PMID: 8765173

5

Vernier zone residue 4 of mouse subgroup II kappa light chains is a critical determinant for antigen recognition.

de Haard H, Kazemier B, van der Bent A, Oudshoorn P, Boender P, Arends JW, van Gemen B. de Haard H, et al. Immunotechnology. 1999 Mar;4(3-4):203-15. doi: 10.1016/s1380-2933(98)00021-9. Immunotechnology. 1999. PMID: 10231090

6

Combining somatic mutations present in different in vivo affinity-matured antibodies isolated from immunized Lama glama yields ultra-potent antibody therapeutics.

Klarenbeek A, Blanchetot C, Schragel G, Sadi AS, Ongenae N, Hemrika W, Wijdenes J, Spinelli S, Desmyter A, Cambillau C, Hultberg A, Kretz-Rommel A, Dreier T, De Haard HJ, Roovers RC. Klarenbeek A, et al. Among authors: de haard hj. Protein Eng Des Sel. 2016 Apr;29(4):123-33. doi: 10.1093/protein/gzw003. Epub 2016 Mar 5. Protein Eng Des Sel. 2016. PMID: 26945588

7

Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.

Klarenbeek A, El Mazouari K, Desmyter A, Blanchetot C, Hultberg A, de Jonge N, Roovers RC, Cambillau C, Spinelli S, Del-Favero J, Verrips T, de Haard HJ, Achour I. Klarenbeek A, et al. Among authors: de haard hj. MAbs. 2015;7(4):693-706. doi: 10.1080/19420862.2015.1046648. MAbs. 2015. PMID: 26018625 Free PMC article.

8

Efficient inhibition of EGFR signaling and of tumour growth by antagonistic anti-EFGR Nanobodies.

Roovers RC, Laeremans T, Huang L, De Taeye S, Verkleij AJ, Revets H, de Haard HJ, van Bergen en Henegouwen PM. Roovers RC, et al. Among authors: de haard hj, de taeye s. Cancer Immunol Immunother. 2007 Mar;56(3):303-317. doi: 10.1007/s00262-006-0180-4. Cancer Immunol Immunother. 2007. PMID: 16738850 Free PMC article.

9

Directing HIV-1 for degradation by non-target cells, using bi-specific single-chain llama antibodies.

Stam JC, de Maat S, de Jong D, Arens M, van Lint F, Gharu L, van Roosmalen MH, Roovers RC, Strokappe NM, Wagner R, Kliche A, de Haard HJ, van Bergen En Henegouwen PM, Nijhuis M, Verrips CT. Stam JC, et al. Among authors: de haard hj. Sci Rep. 2022 Aug 4;12(1):13413. doi: 10.1038/s41598-022-15993-y. Sci Rep. 2022. PMID: 35927444 Free PMC article.

10

Generation of a family-specific phage library of llama single chain antibody fragments that neutralize HIV-1.

Koh WW, Steffensen S, Gonzalez-Pajuelo M, Hoorelbeke B, Gorlani A, Szynol A, Forsman A, Aasa-Chapman MM, de Haard H, Verrips T, Weiss RA. Koh WW, et al. J Biol Chem. 2010 Jun 18;285(25):19116-24. doi: 10.1074/jbc.M110.116699. Epub 2010 Apr 16. J Biol Chem. 2010. PMID: 20400507 Free PMC article.

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