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5-fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-yl carbonyl)-2-pyridinyl]benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor antagonists.
Aranapakam V, Albright JD, Grosu GT, Delos Santos EG, Chan PS, Coupet J, Ru X, Saunders T, Mazandarani H. Aranapakam V, et al. Among authors: ru x. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1737-40. doi: 10.1016/s0960-894x(99)00279-6. Bioorg Med Chem Lett. 1999. PMID: 10406633
5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors.
Albright JD, Reich MF, Delos Santos EG, Dusza JP, Sum FW, Venkatesan AM, Coupet J, Chan PS, Ru X, Mazandarani H, Bailey T. Albright JD, et al. Among authors: ru x. J Med Chem. 1998 Jul 2;41(14):2442-4. doi: 10.1021/jm980179c. J Med Chem. 1998. PMID: 9651149 Clinical Trial. No abstract available.
VPA-985, a nonpeptide orally active and selective vasopressin V2 receptor antagonist.
Chan PS, Coupet J, Park HC, Lai F, Hartupee D, Cervoni P, Dusza JP, Albright JD, Ru X, Mazandarani H, Tanikella T, Shepherd C, Ochalski L, Bailey T, Lock TY, Ning X, Taylor JR, Spinelli W. Chan PS, et al. Among authors: ru x. Adv Exp Med Biol. 1998;449:439-43. doi: 10.1007/978-1-4615-4871-3_55. Adv Exp Med Biol. 1998. PMID: 10026835 Review. No abstract available.
302 results