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Prognostic significance of the S-phase fraction of light-chain-restricted cytoplasmic immunoglobulin (cIg) positive plasma cells in patients with newly diagnosed multiple myeloma enrolled on Eastern Cooperative Oncology Group treatment trial E9486.
Trendle MC, Leong T, Kyle RA, Katzmann JA, Oken MM, Kay NE, Van Ness BG, Greipp PR. Trendle MC, et al. Am J Hematol. 1999 Aug;61(4):232-7. doi: 10.1002/(sici)1096-8652(199908)61:4<232::aid-ajh2>3.0.co;2-t. Am J Hematol. 1999. PMID: 10440908 Free article.
A validated FISH trisomy index demonstrates the hyperdiploid and nonhyperdiploid dichotomy in MGUS.
Chng WJ, Van Wier SA, Ahmann GJ, Winkler JM, Jalal SM, Bergsagel PL, Chesi M, Trendle MC, Oken MM, Blood E, Henderson K, Santana-Dávila R, Kyle RA, Gertz MA, Lacy MQ, Dispenzieri A, Greipp PR, Fonseca R. Chng WJ, et al. Among authors: trendle mc. Blood. 2005 Sep 15;106(6):2156-61. doi: 10.1182/blood-2005-02-0761. Epub 2005 May 26. Blood. 2005. PMID: 15920009 Free PMC article.
Ploidy status rarely changes in myeloma patients at disease progression.
Chng WJ, Winkler JM, Greipp PR, Jalal SM, Bergsagel PL, Chesi M, Trendle MC, Ahmann GJ, Henderson K, Blood E, Oken MM, Hulbert A, Van Wier SA, Santana-Dávila R, Kyle RA, Gertz MA, Lacy MQ, Dispenzieri A, Fonseca R. Chng WJ, et al. Among authors: trendle mc. Leuk Res. 2006 Mar;30(3):266-71. doi: 10.1016/j.leukres.2005.07.004. Epub 2005 Aug 18. Leuk Res. 2006. PMID: 16111750 Clinical Trial.