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Page 1
2,4-Thiazolidinediones as potent and selective human beta3 agonists.
Hu B, Ellingboe J, Gunawan I, Han S, Largis E, Li Z, Malamas M, Mulvey R, Oliphant A, Sum FW, Tillett J, Wong V. Hu B, et al. Among authors: sum fw. Bioorg Med Chem Lett. 2001 Mar 26;11(6):757-60. doi: 10.1016/s0960-894x(01)00063-4. Bioorg Med Chem Lett. 2001. PMID: 11277513
5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors.
Albright JD, Reich MF, Delos Santos EG, Dusza JP, Sum FW, Venkatesan AM, Coupet J, Chan PS, Ru X, Mazandarani H, Bailey T. Albright JD, et al. Among authors: sum fw. J Med Chem. 1998 Jul 2;41(14):2442-4. doi: 10.1021/jm980179c. J Med Chem. 1998. PMID: 9651149 Clinical Trial. No abstract available.
Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.
Venkatesan AM, Agarwal A, Abe T, Ushirogochi H, Yamamura I, Ado M, Tsuyoshi T, Dos Santos O, Gu Y, Sum FW, Li Z, Francisco G, Lin YI, Petersen PJ, Yang Y, Kumagai T, Weiss WJ, Shlaes DM, Knox JR, Mansour TS. Venkatesan AM, et al. Among authors: sum fw. J Med Chem. 2006 Jul 27;49(15):4623-37. doi: 10.1021/jm060021p. J Med Chem. 2006. PMID: 16854068
Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.
McKew JC, Lee KL, Shen MW, Thakker P, Foley MA, Behnke ML, Hu B, Sum FW, Tam S, Hu Y, Chen L, Kirincich SJ, Michalak R, Thomason J, Ipek M, Wu K, Wooder L, Ramarao MK, Murphy EA, Goodwin DG, Albert L, Xu X, Donahue F, Ku MS, Keith J, Nickerson-Nutter CL, Abraham WM, Williams C, Hegen M, Clark JD. McKew JC, et al. Among authors: sum fw. J Med Chem. 2008 Jun 26;51(12):3388-413. doi: 10.1021/jm701467e. Epub 2008 May 23. J Med Chem. 2008. PMID: 18498150
Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization.
McKew JC, Foley MA, Thakker P, Behnke ML, Lovering FE, Sum FW, Tam S, Wu K, Shen MW, Zhang W, Gonzalez M, Liu S, Mahadevan A, Sard H, Khor SP, Clark JD. McKew JC, et al. Among authors: sum fw. J Med Chem. 2006 Jan 12;49(1):135-58. doi: 10.1021/jm0507882. J Med Chem. 2006. PMID: 16392799
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