Smits R - Search Results

1

The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model.

van der Houven van Oordt CW, Smits R, Schouten TG, Houwing-Duistermaat JJ, Williamson SL, Luz A, Meera Khan P, van der Eb AJ, Breuer ML, Fodde R. van der Houven van Oordt CW, et al. Among authors: smits r. Genes Chromosomes Cancer. 1999 Mar;24(3):191-8. doi: 10.1002/(sici)1098-2264(199903)24:3<191::aid-gcc3>3.0.co;2-l. Genes Chromosomes Cancer. 1999. PMID: 10451698

2

Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse.

Kielman MF, Smits R, Devi TS, Fodde R, Bernini LF. Kielman MF, et al. Among authors: smits r. Mamm Genome. 1993;4(6):314-23. doi: 10.1007/BF00357090. Mamm Genome. 1993. PMID: 8318735

3

Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.

Smits R, Kartheuser A, Jagmohan-Changur S, Leblanc V, Breukel C, de Vries A, van Kranen H, van Krieken JH, Williamson S, Edelmann W, Kucherlapati R, KhanPM, Fodde R. Smits R, et al. Carcinogenesis. 1997 Feb;18(2):321-7. doi: 10.1093/carcin/18.2.321. Carcinogenesis. 1997. PMID: 9054624

4

Intestinal and extra-intestinal tumor multiplicities in the Apc1638N mouse model after exposure to X-rays.

van der Houven van Oordt CW, Smits R, Williamson SL, Luz A, Khan PM, Fodde R, van der Eb AJ, Breuer ML. van der Houven van Oordt CW, et al. Among authors: smits r. Carcinogenesis. 1997 Nov;18(11):2197-203. doi: 10.1093/carcin/18.11.2197. Carcinogenesis. 1997. PMID: 9395221

5

Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts.

Smits R, van der Houven van Oordt W, Luz A, Zurcher C, Jagmohan-Changur S, Breukel C, Khan PM, Fodde R. Smits R, et al. Gastroenterology. 1998 Feb;114(2):275-83. doi: 10.1016/s0016-5085(98)70478-0. Gastroenterology. 1998. PMID: 9453487

6

Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway.

Wielenga VJ, Smits R, Korinek V, Smit L, Kielman M, Fodde R, Clevers H, Pals ST. Wielenga VJ, et al. Among authors: smits r. Am J Pathol. 1999 Feb;154(2):515-23. doi: 10.1016/S0002-9440(10)65297-2. Am J Pathol. 1999. PMID: 10027409 Free PMC article.

7

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development.

Smits R, Kielman MF, Breukel C, Zurcher C, Neufeld K, Jagmohan-Changur S, Hofland N, van Dijk J, White R, Edelmann W, Kucherlapati R, Khan PM, Fodde R. Smits R, et al. Genes Dev. 1999 May 15;13(10):1309-21. doi: 10.1101/gad.13.10.1309. Genes Dev. 1999. PMID: 10346819 Free PMC article.

8

Mechanisms of APC-driven tumorigenesis: lessons from mouse models.

Fodde R, Smits R, Hofland N, Kielman M, Meera Khan P. Fodde R, et al. Among authors: smits r. Cytogenet Cell Genet. 1999;86(2):105-11. doi: 10.1159/000015361. Cytogenet Cell Genet. 1999. PMID: 10545699 Review.

9

A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor.

Couture J, Mitri A, Lagace R, Smits R, Berk T, Bouchard HL, Fodde R, Alman B, Bapat B. Couture J, et al. Among authors: smits r. Clin Genet. 2000 Mar;57(3):205-12. doi: 10.1034/j.1399-0004.2000.570306.x. Clin Genet. 2000. PMID: 10782927

10

Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity.

Smits R, Hofland N, Edelmann W, Geugien M, Jagmohan-Changur S, Albuquerque C, Breukel C, Kucherlapati R, Kielman MF, Fodde R. Smits R, et al. Genes Chromosomes Cancer. 2000 Nov;29(3):229-39. doi: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1033>3.0.co;2-r. Genes Chromosomes Cancer. 2000. PMID: 10992298

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