Bridger G - Search Results

1

Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA.

Van Gelder J, Witvrouw M, Pannecouque C, Henson G, Bridger G, Naesens L, De Clercq E, Annaert P, Shafiee M, Van den Mooter G, Kinget R, Augustijns P. Van Gelder J, et al. Among authors: bridger g. Int J Pharm. 1999 Sep 20;186(2):127-36. doi: 10.1016/s0378-5173(99)00150-7. Int J Pharm. 1999. PMID: 10486430

2

Antiviral activity of the bicyclam derivative JM3100 against drug-resistant strains of human immunodeficiency virus type 1.

Esté JA, De Vreese K, Witvrouw M, Schmit JC, Vandamme AM, Anné J, Desmyter J, Henson GW, Bridger G, De Clercq E. Esté JA, et al. Among authors: bridger g. Antiviral Res. 1996 Mar;29(2-3):297-307. doi: 10.1016/0166-3542(95)00936-1. Antiviral Res. 1996. PMID: 8739608

3

Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100.

Hatse S, Princen K, Gerlach LO, Bridger G, Henson G, De Clercq E, Schwartz TW, Schols D. Hatse S, et al. Among authors: bridger g. Mol Pharmacol. 2001 Jul;60(1):164-73. doi: 10.1124/mol.60.1.164. Mol Pharmacol. 2001. PMID: 11408611

4

Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.

Hatse S, Princen K, Bridger G, De Clercq E, Schols D. Hatse S, et al. Among authors: bridger g. FEBS Lett. 2002 Sep 11;527(1-3):255-62. doi: 10.1016/s0014-5793(02)03143-5. FEBS Lett. 2002. PMID: 12220670 Free article.

5

AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice.

Matthys P, Hatse S, Vermeire K, Wuyts A, Bridger G, Henson GW, De Clercq E, Billiau A, Schols D. Matthys P, et al. Among authors: bridger g. J Immunol. 2001 Oct 15;167(8):4686-92. doi: 10.4049/jimmunol.167.8.4686. J Immunol. 2001. PMID: 11591799

6

The antiviral activity of the CXCR4 antagonist AMD3100 is independent of the cytokine-induced CXCR4/HIV coreceptor expression level.

Princen K, Hatse S, Vermeire K, Bridger GJ, Skerlj RT, De Clercq E, Schols D. Princen K, et al. AIDS Res Hum Retroviruses. 2003 Dec;19(12):1135-9. doi: 10.1089/088922203771881239. AIDS Res Hum Retroviruses. 2003. PMID: 14709250

7

X4 HIV-1 induces neuroblastoma cell death by interference with CXCL12/CXCR4 interaction.

Hatse S, Bridger G, de Clercq E, Schols D. Hatse S, et al. Among authors: bridger g. Cell Mol Biol (Noisy-le-grand). 2003;49 Online Pub:OL443-52. Cell Mol Biol (Noisy-le-grand). 2003. PMID: 14995074

8

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4.

Bridger GJ, Skerlj RT, Padmanabhan S, Martellucci SA, Henson GW, Struyf S, Witvrouw M, Schols D, De Clercq E. Bridger GJ, et al. J Med Chem. 1999 Sep 23;42(19):3971-81. doi: 10.1021/jm990211i. J Med Chem. 1999. PMID: 10508445

9

Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry.

Hatse S, Princen K, Vermeire K, Gerlach LO, Rosenkilde MM, Schwartz TW, Bridger G, De Clercq E, Schols D. Hatse S, et al. Among authors: bridger g. FEBS Lett. 2003 Jul 10;546(2-3):300-6. doi: 10.1016/s0014-5793(03)00609-4. FEBS Lett. 2003. PMID: 12832058 Free article.

10

The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding.

De Vreese K, Reymen D, Griffin P, Steinkasserer A, Werner G, Bridger GJ, Esté J, James W, Henson GW, Desmyter J, Anné J, De Clercq I. De Vreese K, et al. Among authors: bridger gj. Antiviral Res. 1996 Mar;29(2-3):209-19. doi: 10.1016/0166-3542(95)00837-3. Antiviral Res. 1996. PMID: 8739600

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