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Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.
Yamagata K, Nammo T, Moriwaki M, Ihara A, Iizuka K, Yang Q, Satoh T, Li M, Uenaka R, Okita K, Iwahashi H, Zhu Q, Cao Y, Imagawa A, Tochino Y, Hanafusa T, Miyagawa J, Matsuzawa Y. Yamagata K, et al. Among authors: miyagawa j. Diabetes. 2002 Jan;51(1):114-23. doi: 10.2337/diabetes.51.1.114. Diabetes. 2002. PMID: 11756330
The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation.
Fukui K, Yang Q, Cao Y, Takahashi N, Hatakeyama H, Wang H, Wada J, Zhang Y, Marselli L, Nammo T, Yoneda K, Onishi M, Higashiyama S, Matsuzawa Y, Gonzalez FJ, Weir GC, Kasai H, Shimomura I, Miyagawa J, Wollheim CB, Yamagata K. Fukui K, et al. Among authors: miyagawa j. Cell Metab. 2005 Dec;2(6):373-84. doi: 10.1016/j.cmet.2005.11.003. Cell Metab. 2005. PMID: 16330323 Free article.
Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization.
Yoshiuchi I, Yamagata K, Yang Q, Iwahashi H, Okita K, Yamamoto K, Oue T, Imagawa A, Hamaguchi T, Yamasaki T, Horikawa Y, Satoh T, Nakajima H, Miyazaki J, Higashiyama S, Miyagawa J, Namba M, Hanafusa T, Matsuzawa Y. Yoshiuchi I, et al. Among authors: miyagawa j. Diabetologia. 1999 May;42(5):621-6. doi: 10.1007/s001250051204. Diabetologia. 1999. PMID: 10333057
233 results