Wollheim CB - Search Results

1

Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta.

Okita K, Yang Q, Yamagata K, Hangenfeldt KA, Miyagawa J, Kajimoto Y, Nakajima H, Namba M, Wollheim CB, Hanafusa T, Matsuzawa Y. Okita K, et al. Among authors: wollheim cb. Biochem Biophys Res Commun. 1999 Sep 24;263(2):566-9. doi: 10.1006/bbrc.1999.1412. Biochem Biophys Res Commun. 1999. PMID: 10491332

2

Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells.

Yang Q, Yamagata K, Fukui K, Cao Y, Nammo T, Iwahashi H, Wang H, Matsumura I, Hanafusa T, Bucala R, Wollheim CB, Miyagawa J, Matsuzawa Y. Yang Q, et al. Among authors: wollheim cb. Diabetes. 2002 Jun;51(6):1785-92. doi: 10.2337/diabetes.51.6.1785. Diabetes. 2002. PMID: 12031966

3

The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation.

Fukui K, Yang Q, Cao Y, Takahashi N, Hatakeyama H, Wang H, Wada J, Zhang Y, Marselli L, Nammo T, Yoneda K, Onishi M, Higashiyama S, Matsuzawa Y, Gonzalez FJ, Weir GC, Kasai H, Shimomura I, Miyagawa J, Wollheim CB, Yamagata K. Fukui K, et al. Among authors: wollheim cb. Cell Metab. 2005 Dec;2(6):373-84. doi: 10.1016/j.cmet.2005.11.003. Cell Metab. 2005. PMID: 16330323 Free article.

4

Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.

Pongratz RL, Kibbey RG, Kirkpatrick CL, Zhao X, Pontoglio M, Yaniv M, Wollheim CB, Shulman GI, Cline GW. Pongratz RL, et al. Among authors: wollheim cb. J Biol Chem. 2009 Jun 19;284(25):16808-16821. doi: 10.1074/jbc.M807723200. Epub 2009 Apr 17. J Biol Chem. 2009. PMID: 19376774 Free PMC article.

5

Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice.

Hagenfeldt-Johansson KA, Herrera PL, Wang H, Gjinovci A, Ishihara H, Wollheim CB. Hagenfeldt-Johansson KA, et al. Among authors: wollheim cb. Endocrinology. 2001 Dec;142(12):5311-20. doi: 10.1210/endo.142.12.8592. Endocrinology. 2001. PMID: 11713231

6

Experimental models of transcription factor-associated maturity-onset diabetes of the young.

Wang H, Hagenfeldt-Johansson K, Otten LA, Gauthier BR, Herrera PL, Wollheim CB. Wang H, et al. Among authors: wollheim cb. Diabetes. 2002 Dec;51 Suppl 3:S333-42. doi: 10.2337/diabetes.51.2007.s333. Diabetes. 2002. PMID: 12475772 Review.

7

Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.

Wang H, Maechler P, Hagenfeldt KA, Wollheim CB. Wang H, et al. Among authors: wollheim cb. EMBO J. 1998 Nov 16;17(22):6701-13. doi: 10.1093/emboj/17.22.6701. EMBO J. 1998. PMID: 9822613 Free PMC article.

8

Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha.

Bartoov-Shifman R, Hertz R, Wang H, Wollheim CB, Bar-Tana J, Walker MD. Bartoov-Shifman R, et al. Among authors: wollheim cb. J Biol Chem. 2002 Jul 19;277(29):25914-9. doi: 10.1074/jbc.M201582200. Epub 2002 May 6. J Biol Chem. 2002. PMID: 11994285 Free article.

9

Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in type II diabetes.

Wollheim CB. Wollheim CB. Diabetologia. 2000 Mar;43(3):265-77. doi: 10.1007/s001250050044. Diabetologia. 2000. PMID: 10768087 Review.

10

Synergistic activation of NF-kappab and inducible isoform of nitric oxide synthase induction by interferon-gamma and tumor necrosis factor-alpha in INS-1 cells.

Sekine N, Ishikawa T, Okazaki T, Hayashi M, Wollheim CB, Fujita T. Sekine N, et al. Among authors: wollheim cb. J Cell Physiol. 2000 Jul;184(1):46-57. doi: 10.1002/(SICI)1097-4652(200007)184:1<46::AID-JCP5>3.0.CO;2-L. J Cell Physiol. 2000. PMID: 10825233

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