Sorensen PH - Search Results

1

Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein.

Hahm KB, Cho K, Lee C, Im YH, Chang J, Choi SG, Sorensen PH, Thiele CJ, Kim SJ. Hahm KB, et al. Among authors: sorensen ph. Nat Genet. 1999 Oct;23(2):222-7. doi: 10.1038/13854. Nat Genet. 1999. PMID: 10508522

2

EWS-FLI1, EWS-ERG, and EWS-ETV1 oncoproteins of Ewing tumor family all suppress transcription of transforming growth factor beta type II receptor gene.

Im YH, Kim HT, Lee C, Poulin D, Welford S, Sorensen PH, Denny CT, Kim SJ. Im YH, et al. Among authors: sorensen ph. Cancer Res. 2000 Mar 15;60(6):1536-40. Cancer Res. 2000. PMID: 10749119

3

The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-beta signaling by inactivating the TGF-beta type II receptor.

Jin W, Kim BC, Tognon C, Lee HJ, Patel S, Lannon CL, Maris JM, Triche TJ, Sorensen PH, Kim SJ. Jin W, et al. Among authors: sorensen ph. Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16239-44. doi: 10.1073/pnas.0503137102. Epub 2005 Oct 28. Proc Natl Acad Sci U S A. 2005. PMID: 16258068 Free PMC article.

4

Cellular transformation and activation of the phosphoinositide-3-kinase-Akt cascade by the ETV6-NTRK3 chimeric tyrosine kinase requires c-Src.

Jin W, Yun C, Hobbie A, Martin MJ, Sorensen PH, Kim SJ. Jin W, et al. Among authors: sorensen ph. Cancer Res. 2007 Apr 1;67(7):3192-200. doi: 10.1158/0008-5472.CAN-06-3526. Cancer Res. 2007. PMID: 17409427

5

A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation.

Lannon CL, Martin MJ, Tognon CE, Jin W, Kim SJ, Sorensen PH. Lannon CL, et al. Among authors: sorensen ph. J Biol Chem. 2004 Feb 20;279(8):6225-34. doi: 10.1074/jbc.M307388200. Epub 2003 Dec 9. J Biol Chem. 2004. PMID: 14668342 Free article.

6

A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG.

Sorensen PH, Lessnick SL, Lopez-Terrada D, Liu XF, Triche TJ, Denny CT. Sorensen PH, et al. Nat Genet. 1994 Feb;6(2):146-51. doi: 10.1038/ng0294-146. Nat Genet. 1994. PMID: 8162068

7

Novel identification of STAT1 as a crucial mediator of ETV6-NTRK3-induced tumorigenesis.

Park J, Kim J, Park B, Yang KM, Sun EJ, Tognon CE, Sorensen PH, Kim SJ. Park J, et al. Among authors: sorensen ph. Oncogene. 2018 Apr;37(17):2270-2284. doi: 10.1038/s41388-017-0102-2. Epub 2018 Feb 2. Oncogene. 2018. PMID: 29391602

8

Lin28 promotes transformation and is associated with advanced human malignancies.

Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, O'Sullivan M, Lu J, Phillips LA, Lockhart VL, Shah SP, Tanwar PS, Mermel CH, Beroukhim R, Azam M, Teixeira J, Meyerson M, Hughes TP, Llovet JM, Radich J, Mullighan CG, Golub TR, Sorensen PH, Daley GQ. Viswanathan SR, et al. Among authors: sorensen ph. Nat Genet. 2009 Jul;41(7):843-8. doi: 10.1038/ng.392. Epub 2009 May 31. Nat Genet. 2009. PMID: 19483683 Free PMC article.

9

A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma.

Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH. Knezevich SR, et al. Among authors: sorensen ph. Nat Genet. 1998 Feb;18(2):184-7. doi: 10.1038/ng0298-184. Nat Genet. 1998. PMID: 9462753

10

EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma.

Ginsberg JP, de Alava E, Ladanyi M, Wexler LH, Kovar H, Paulussen M, Zoubek A, Dockhorn-Dworniczak B, Juergens H, Wunder JS, Andrulis IL, Malik R, Sorensen PH, Womer RB, Barr FG. Ginsberg JP, et al. Among authors: sorensen ph. J Clin Oncol. 1999 Jun;17(6):1809-14. doi: 10.1200/JCO.1999.17.6.1809. J Clin Oncol. 1999. PMID: 10561219

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