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Parathyroid hormone-related proteins is abundant in osteoarthritic cartilage, and the parathyroid hormone-related protein 1-173 isoform is selectively induced by transforming growth factor beta in articular chondrocytes and suppresses generation of extracellular inorganic pyrophosphate.
Terkeltaub R, Lotz M, Johnson K, Deng D, Hashimoto S, Goldring MB, Burton D, Deftos LJ. Terkeltaub R, et al. Among authors: johnson k. Arthritis Rheum. 1998 Dec;41(12):2152-64. doi: 10.1002/1529-0131(199812)41:12<2152::AID-ART10>3.0.CO;2-X. Arthritis Rheum. 1998. PMID: 9870872
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