Macfarlane WM - Search Results

1

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes.

Macfarlane WM, Frayling TM, Ellard S, Evans JC, Allen LI, Bulman MP, Ayres S, Shepherd M, Clark P, Millward A, Demaine A, Wilkin T, Docherty K, Hattersley AT. Macfarlane WM, et al. J Clin Invest. 1999 Nov;104(9):R33-9. doi: 10.1172/JCI7449. J Clin Invest. 1999. PMID: 10545530 Free PMC article.

2

IUF1, a nutrient responsive transcription factor in the pancreatic beta-cells.

Macfarlane WM, Docherty K. Macfarlane WM, et al. Biochem Soc Trans. 1996 May;24(2):239S. doi: 10.1042/bst024239s. Biochem Soc Trans. 1996. PMID: 8736897 No abstract available.

3

The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells.

Macfarlane WM, Smith SB, James RF, Clifton AD, Doza YN, Cohen P, Docherty K. Macfarlane WM, et al. J Biol Chem. 1997 Aug 15;272(33):20936-44. doi: 10.1074/jbc.272.33.20936. J Biol Chem. 1997. PMID: 9252422 Free article.

4

Impaired expression of transcription factor IUF1 in a pancreatic beta-cell line derived from a patient with persistent hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis).

Macfarlane WM, Cragg H, Docherty HM, Read ML, James RF, Aynsley-Green A, Docherty K. Macfarlane WM, et al. FEBS Lett. 1997 Aug 18;413(2):304-8. doi: 10.1016/s0014-5793(97)00874-0. FEBS Lett. 1997. PMID: 9280302 Free article.

5

Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells.

Macfarlane WM, McKinnon CM, Felton-Edkins ZA, Cragg H, James RF, Docherty K. Macfarlane WM, et al. J Biol Chem. 1999 Jan 8;274(2):1011-6. doi: 10.1074/jbc.274.2.1011. J Biol Chem. 1999. PMID: 9873045 Free article.

6

Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells.

Wu H, MacFarlane WM, Tadayyon M, Arch JR, James RF, Docherty K. Wu H, et al. Among authors: macfarlane wm. Biochem J. 1999 Dec 15;344 Pt 3(Pt 3):813-8. Biochem J. 1999. PMID: 10585868 Free PMC article.

7

Glucose regulates islet amyloid polypeptide gene transcription in a PDX1- and calcium-dependent manner.

Macfarlane WM, Campbell SC, Elrick LJ, Oates V, Bermano G, Lindley KJ, Aynsley-Green A, Dunne MJ, James RF, Docherty K. Macfarlane WM, et al. J Biol Chem. 2000 May 19;275(20):15330-5. doi: 10.1074/jbc.M908045199. J Biol Chem. 2000. PMID: 10748090 Free article.

8

Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2+.

Macfarlane WM, Shepherd RM, Cosgrove KE, James RF, Dunne MJ, Docherty K. Macfarlane WM, et al. Diabetes. 2000 Mar;49(3):418-23. doi: 10.2337/diabetes.49.3.418. Diabetes. 2000. PMID: 10868963

9

Regulation of insulin gene transcription by nutrients.

Docherty K, Macfarlane WM, Read ML, Smith SB, Wilson ME, Bujalska I, Gilligan M. Docherty K, et al. Among authors: macfarlane wm. Biochem Soc Trans. 1996 May;24(2):368-72. doi: 10.1042/bst0240368. Biochem Soc Trans. 1996. PMID: 8736765 Review. No abstract available.

10

Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy.

MacFarlane WM, Chapman JC, Shepherd RM, Hashmi MN, Kamimura N, Cosgrove KE, O'Brien RE, Barnes PD, Hart AW, Docherty HM, Lindley KJ, Aynsley-Green A, James RF, Docherty K, Dunne MJ. MacFarlane WM, et al. J Biol Chem. 1999 Nov 26;274(48):34059-66. doi: 10.1074/jbc.274.48.34059. J Biol Chem. 1999. PMID: 10567373 Free article.

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