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Macrophage specific overexpression of the human macrophage scavenger receptor in transgenic mice, using a 180-kb yeast artificial chromosome, leads to enhanced foam cell formation of isolated peritoneal macrophages.
de Winther MP, van Dijk KW, van Vlijmen BJ, Gijbels MJ, Heus JJ, Wijers ER, van den Bos AC, Breuer M, Frants RR, Havekes LM, Hofker MH. de Winther MP, et al. Among authors: havekes lm. Atherosclerosis. 1999 Dec;147(2):339-47. doi: 10.1016/s0021-9150(99)00204-x. Atherosclerosis. 1999. PMID: 10559520
Genomic analysis of the response of mouse models to high-fat feeding shows a major role of nuclear receptors in the simultaneous regulation of lipid and inflammatory genes.
Kreeft AJ, Moen CJ, Porter G, Kasanmoentalib S, Sverdlov R, van Gorp PJ, Havekes LM, Frants RR, Hofker MH. Kreeft AJ, et al. Among authors: havekes lm. Atherosclerosis. 2005 Oct;182(2):249-57. doi: 10.1016/j.atherosclerosis.2005.01.049. Epub 2005 Mar 16. Atherosclerosis. 2005. PMID: 16159597
In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway.
Jong MC, Dahlmans VE, van Gorp PJ, van Dijk KW, Breuer ML, Hofker MH, Havekes LM. Jong MC, et al. Among authors: havekes lm. J Clin Invest. 1996 Nov 15;98(10):2259-67. doi: 10.1172/JCI119036. J Clin Invest. 1996. PMID: 8941642 Free PMC article.
448 results