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Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects.
Simon LS, Lanza FL, Lipsky PE, Hubbard RC, Talwalker S, Schwartz BD, Isakson PC, Geis GS. Simon LS, et al. Among authors: isakson pc. Arthritis Rheum. 1998 Sep;41(9):1591-602. doi: 10.1002/1529-0131(199809)41:9<1591::AID-ART9>3.0.CO;2-J. Arthritis Rheum. 1998. PMID: 9751091 Clinical Trial.
Effects of celecoxib and naproxen on renal function in the elderly.
Whelton A, Schulman G, Wallemark C, Drower EJ, Isakson PC, Verburg KM, Geis GS. Whelton A, et al. Among authors: isakson pc. Arch Intern Med. 2000 May 22;160(10):1465-70. doi: 10.1001/archinte.160.10.1465. Arch Intern Med. 2000. PMID: 10826459 Clinical Trial.
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, Docter S, Graneto MJ, Lee LF, Malecha JW, Miyashiro JM, Rogers RS, Rogier DJ, Yu SS, AndersonGD, Burton EG, Cogburn JN, Gregory SA, Koboldt CM, Perkins WE, Seibert K, Veenhuizen AW, Zhang YY, Isakson PC. Penning TD, et al. Among authors: isakson pc. J Med Chem. 1997 Apr 25;40(9):1347-65. doi: 10.1021/jm960803q. J Med Chem. 1997. PMID: 9135032
131 results