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A structural change in the kinesin motor protein that drives motility.
Rice S, Lin AW, Safer D, Hart CL, Naber N, Carragher BO, Cain SM, Pechatnikova E, Wilson-Kubalek EM, Whittaker M, Pate E, Cooke R, Taylor EW, Milligan RA, Vale RD. Rice S, et al. Nature. 1999 Dec 16;402(6763):778-84. doi: 10.1038/45483. Nature. 1999. PMID: 10617199
The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding.
Bodrug T, Wilson-Kubalek EM, Nithianantham S, Thompson AF, Alfieri A, Gaska I, Major J, Debs G, Inagaki S, Gutierrez P, Gheber L, McKenney RJ, Sindelar CV, Milligan R, Stumpff J, Rosenfeld SS, Forth ST, Al-Bassam J. Bodrug T, et al. Among authors: wilson kubalek em. Elife. 2020 Jan 20;9:e51131. doi: 10.7554/eLife.51131. Elife. 2020. PMID: 31958056 Free PMC article.
37 results