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1alpha,25-dihydroxy-16-ene-23-yne-vitamin D3 and 1alpha,25-dihydroxy-16-ene-23-yne-20-epi-vitamin D3: analogs of 1alpha,25-dihydroxyvitamin D3 that resist metabolism through the C-24 oxidation pathway are metabolized through the C-3 epimerization pathway.
Reddy GS, Rao DS, Siu-Caldera ML, Astecker N, Weiskopf A, Vouros P, Sasso GJ, Manchand PS, Uskokovic MR. Reddy GS, et al. Among authors: rao ds. Arch Biochem Biophys. 2000 Nov 15;383(2):197-205. doi: 10.1006/abbi.2000.2074. Arch Biochem Biophys. 2000. PMID: 11185554
The biological activities of 1alpha,25-dihydroxyvitamin D3 and its synthetic analog 1alpha,25-dihydroxy-16-ene-vitamin D3 in normal human osteoblastic cells and human osteosarcoma SaOS-2 cells are modulated by 17-beta estradiol and dependent on stage of differentiation.
Rao LG, Liu LJ, Rawlins MR, McBroom RJ, Murray TM, Reddy GS, Uskokovic MR, Rao DS, Sutherland MK. Rao LG, et al. Among authors: rao ds. Biol Pharm Bull. 2001 Mar;24(3):242-8. doi: 10.1248/bpb.24.242. Biol Pharm Bull. 2001. PMID: 11256478 Free article.
Synthesis and biological activities of the two C(23) epimers of 1alpha,23,25-trihydroxy-24-oxo-19-nor-vitamin D(3): novel analogs of 1alpha,23(S),25-trihydroxy-24-oxo-vitamin D(3), a natural metabolite of 1alpha,25-dihydroxyvitamin D(3).
Lee NE, Williard PG, Brown AJ, Campbell MJ, Koeffler HP, Peleg S, Rao DS, Reddy GS. Lee NE, et al. Among authors: rao ds. Steroids. 2000 May;65(5):252-65. doi: 10.1016/s0039-128x(99)00110-5. Steroids. 2000. PMID: 10751637
365 results