Bone R - Search Results

1

Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors.

Soll RM, Lu T, Tomczuk B, Illig CR, Fedde C, Eisennagel S, Bone R, Murphy L, Spurlino J, Salemme FR. Soll RM, et al. Among authors: bone r. Bioorg Med Chem Lett. 2000 Jan 3;10(1):1-4. doi: 10.1016/s0960-894x(99)00632-0. Bioorg Med Chem Lett. 2000. PMID: 10636229

2

A novel series of potent and selective small molecule inhibitors of the complement component C1s.

Subasinghe NL, Ali F, Illig CR, Jonathan Rudolph M, Klein S, Khalil E, Soll RM, Bone RF, Spurlino JC, DesJarlais RL, Crysler CS, Cummings MD, Morris PE Jr, Kilpatrick JM, Sudhakara Babu Y. Subasinghe NL, et al. Among authors: bone rf. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3043-7. doi: 10.1016/j.bmcl.2004.04.034. Bioorg Med Chem Lett. 2004. PMID: 15149641

3

Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors.

Rudolph MJ, Illig CR, Subasinghe NL, Wilson KJ, Hoffman JB, Randle T, Green D, Molloy CJ, Soll RM, Lewandowski F, Zhang M, Bone R, Spurlino JC, Deckman IC, Manthey C, Sharp C, Maguire D, Grasberger BL, DesJarlais RL, Zhou Z. Rudolph MJ, et al. Among authors: bone r. Bioorg Med Chem Lett. 2002 Feb 11;12(3):491-5. doi: 10.1016/s0960-894x(01)00787-9. Bioorg Med Chem Lett. 2002. PMID: 11814826

4

Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors.

Tomczuk B, Lu T, Soll RM, Fedde C, Wang A, Murphy L, Crysler C, Dasgupta M, Eisennagel S, Spurlino J, Bone R. Tomczuk B, et al. Among authors: bone r. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1495-8. doi: 10.1016/s0960-894x(03)00125-2. Bioorg Med Chem Lett. 2003. PMID: 12668020

5

Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis.

Lu T, Markotan T, Coppo F, Tomczuk B, Crysler C, Eisennagel S, Spurlino J, Gremminger L, Soll RM, Giardino EC, Bone R. Lu T, et al. Among authors: bone r. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3727-31. doi: 10.1016/j.bmcl.2004.05.002. Bioorg Med Chem Lett. 2004. PMID: 15203151

6

Serendipity meets precision: the integration of structure-based drug design and combinatorial chemistry for efficient drug discovery.

Salemme FR, Spurlino J, Bone R. Salemme FR, et al. Among authors: bone r. Structure. 1997 Mar 15;5(3):319-24. doi: 10.1016/s0969-2126(97)00189-5. Structure. 1997. PMID: 9083110 Free article. Review.

7

Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes.

Bone R, Lu T, Illig CR, Soll RM, Spurlino JC. Bone R, et al. J Med Chem. 1998 Jun 4;41(12):2068-75. doi: 10.1021/jm970796l. J Med Chem. 1998. PMID: 9622548

8

In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors.

Lu T, Tomczuk B, Illig CR, Bone R, Murphy L, Spurlino J, Salemme FR, Soll RM. Lu T, et al. Among authors: bone r. Bioorg Med Chem Lett. 1998 Jul 7;8(13):1595-600. doi: 10.1016/s0960-894x(98)00290-x. Bioorg Med Chem Lett. 1998. PMID: 9873397

9

Structure-activity and crystallographic analysis of a new class of non-amide-based thrombin inhibitor.

Lu T, Soll RM, Illig CR, Bone R, Murphy L, Spurlino J, Salemme FR, Tomczuk BE. Lu T, et al. Among authors: bone r. Bioorg Med Chem Lett. 2000 Jan 3;10(1):79-82. doi: 10.1016/s0960-894x(99)00617-4. Bioorg Med Chem Lett. 2000. PMID: 10636249

10

Non-peptidic phenyl-based thrombin inhibitors: exploring structural requirements of the S1 specificity pocket with amidines.

Lu T, Tomczuk B, Bone R, Murphy L, Salemme FR, Soll RM. Lu T, et al. Among authors: bone r. Bioorg Med Chem Lett. 2000 Jan 3;10(1):83-5. doi: 10.1016/s0960-894x(99)00616-2. Bioorg Med Chem Lett. 2000. PMID: 10636250

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