Salemme FR - Search Results

1

Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors.

Soll RM, Lu T, Tomczuk B, Illig CR, Fedde C, Eisennagel S, Bone R, Murphy L, Spurlino J, Salemme FR. Soll RM, et al. Among authors: salemme fr. Bioorg Med Chem Lett. 2000 Jan 3;10(1):1-4. doi: 10.1016/s0960-894x(99)00632-0. Bioorg Med Chem Lett. 2000. PMID: 10636229

2

Serendipity meets precision: the integration of structure-based drug design and combinatorial chemistry for efficient drug discovery.

Salemme FR, Spurlino J, Bone R. Salemme FR, et al. Structure. 1997 Mar 15;5(3):319-24. doi: 10.1016/s0969-2126(97)00189-5. Structure. 1997. PMID: 9083110 Free article. Review.

3

In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors.

Lu T, Tomczuk B, Illig CR, Bone R, Murphy L, Spurlino J, Salemme FR, Soll RM. Lu T, et al. Among authors: salemme fr. Bioorg Med Chem Lett. 1998 Jul 7;8(13):1595-600. doi: 10.1016/s0960-894x(98)00290-x. Bioorg Med Chem Lett. 1998. PMID: 9873397

4

Structure-activity and crystallographic analysis of a new class of non-amide-based thrombin inhibitor.

Lu T, Soll RM, Illig CR, Bone R, Murphy L, Spurlino J, Salemme FR, Tomczuk BE. Lu T, et al. Among authors: salemme fr. Bioorg Med Chem Lett. 2000 Jan 3;10(1):79-82. doi: 10.1016/s0960-894x(99)00617-4. Bioorg Med Chem Lett. 2000. PMID: 10636249

5

Non-peptidic phenyl-based thrombin inhibitors: exploring structural requirements of the S1 specificity pocket with amidines.

Lu T, Tomczuk B, Bone R, Murphy L, Salemme FR, Soll RM. Lu T, et al. Among authors: salemme fr. Bioorg Med Chem Lett. 2000 Jan 3;10(1):83-5. doi: 10.1016/s0960-894x(99)00616-2. Bioorg Med Chem Lett. 2000. PMID: 10636250

6

Decrypting the biochemical function of an essential gene from Streptococcus pneumoniae using ThermoFluor technology.

Carver TE, Bordeau B, Cummings MD, Petrella EC, Pucci MJ, Zawadzke LE, Dougherty BA, Tredup JA, Bryson JW, Yanchunas J Jr, Doyle ML, Witmer MR, Nelen MI, DesJarlais RL, Jaeger EP, Devine H, Asel ED, Springer BA, Bone R, Salemme FR, Todd MJ. Carver TE, et al. Among authors: salemme fr. J Biol Chem. 2005 Mar 25;280(12):11704-12. doi: 10.1074/jbc.M413278200. Epub 2005 Jan 5. J Biol Chem. 2005. PMID: 15634672 Free article.

7

Chemical genomics as an emerging paradigm for postgenomic drug discovery.

Salemme FR. Salemme FR. Pharmacogenomics. 2003 May;4(3):257-67. doi: 10.1517/phgs.4.3.257.22692. Pharmacogenomics. 2003. PMID: 12718717 Review.

8

Combinatorial informatics in the post-genomics ERA.

Agrafiotis DK, Lobanov VS, Salemme FR. Agrafiotis DK, et al. Among authors: salemme fr. Nat Rev Drug Discov. 2002 May;1(5):337-46. doi: 10.1038/nrd791. Nat Rev Drug Discov. 2002. PMID: 12120409 Review.

9

Advances in diversity profiling and combinatorial series design.

Agrafiotis DK, Myslik JC, Salemme FR. Agrafiotis DK, et al. Among authors: salemme fr. Mol Divers. 1998-1999;4(1):1-22. doi: 10.1023/a:1009636310640. Mol Divers. 1998. PMID: 10320984 Review.

10

Thermodynamic stability of carbonic anhydrase: measurements of binding affinity and stoichiometry using ThermoFluor.

Matulis D, Kranz JK, Salemme FR, Todd MJ. Matulis D, et al. Among authors: salemme fr. Biochemistry. 2005 Apr 5;44(13):5258-66. doi: 10.1021/bi048135v. Biochemistry. 2005. PMID: 15794662 Free article.

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