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The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore.
Jacotot E, Ravagnan L, Loeffler M, Ferri KF, Vieira HL, Zamzami N, Costantini P, Druillennec S, Hoebeke J, Briand JP, Irinopoulou T, Daugas E, Susin SA, Cointe D, Xie ZH, Reed JC, Roques BP, Kroemer G. Jacotot E, et al. Among authors: costantini p. J Exp Med. 2000 Jan 3;191(1):33-46. doi: 10.1084/jem.191.1.33. J Exp Med. 2000. PMID: 10620603 Free PMC article.
Bid acts on the permeability transition pore complex to induce apoptosis.
Zamzami N, El Hamel C, Maisse C, Brenner C, Muñoz-Pinedo C, Belzacq AS, Costantini P, Vieira H, Loeffler M, Molle G, Kroemer G. Zamzami N, et al. Among authors: costantini p. Oncogene. 2000 Dec 14;19(54):6342-50. doi: 10.1038/sj.onc.1204030. Oncogene. 2000. PMID: 11175349
Molecular characterization of mitochondrial apoptosis-inducing factor.
Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G. Susin SA, et al. Among authors: costantini p. Nature. 1999 Feb 4;397(6718):441-6. doi: 10.1038/17135. Nature. 1999. PMID: 9989411
Two distinct pathways leading to nuclear apoptosis.
Susin SA, Daugas E, Ravagnan L, Samejima K, Zamzami N, Loeffler M, Costantini P, Ferri KF, Irinopoulou T, Prévost MC, Brothers G, Mak TW, Penninger J, Earnshaw WC, Kroemer G. Susin SA, et al. Among authors: costantini p. J Exp Med. 2000 Aug 21;192(4):571-80. doi: 10.1084/jem.192.4.571. J Exp Med. 2000. PMID: 10952727 Free PMC article.
99 results