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Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes.
Grobler JA, Stillmock K, Hu B, Witmer M, Felock P, Espeseth AS, Wolfe A, Egbertson M, Bourgeois M, Melamed J, Wai JS, Young S, Vacca J, Hazuda DJ. Grobler JA, et al. Among authors: wolfe a. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6661-6. doi: 10.1073/pnas.092056199. Epub 2002 May 7. Proc Natl Acad Sci U S A. 2002. PMID: 11997448 Free PMC article.
The role of manganese in promoting multimerization and assembly of human immunodeficiency virus type 1 integrase as a catalytically active complex on immobilized long terminal repeat substrates.
Wolfe AL, Felock PJ, Hastings JC, Blau CU, Hazuda DJ. Wolfe AL, et al. J Virol. 1996 Mar;70(3):1424-32. doi: 10.1128/JVI.70.3.1424-1432.1996. J Virol. 1996. PMID: 8627659 Free PMC article.
Integration requires two discrete biochemical reactions; specific processing of each viral long terminal repeat terminus or donor substrate, and a DNA strand transfer step wherein the processed donor substrate is joined to a nonspecific target DNA. ...J. Hazuda, J. …
Integration requires two discrete biochemical reactions; specific processing of each viral long terminal repeat terminus or donor substrate, …
Inhibition of human immunodeficiency virus integrase by bis-catechols.
LaFemina RL, Graham PL, LeGrow K, Hastings JC, Wolfe A, Young SD, Emini EA, Hazuda DJ. LaFemina RL, et al. Among authors: wolfe a. Antimicrob Agents Chemother. 1995 Feb;39(2):320-4. doi: 10.1128/AAC.39.2.320. Antimicrob Agents Chemother. 1995. PMID: 7726489 Free PMC article.
956 results