Seibert K - Search Results

1

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2.

Talley JJ, Brown DL, Carter JS, Graneto MJ, Koboldt CM, Masferrer JL, Perkins WE, Rogers RS, Shaffer AF, Zhang YY, Zweifel BS, Seibert K. Talley JJ, et al. Among authors: seibert k. J Med Chem. 2000 Mar 9;43(5):775-7. doi: 10.1021/jm990577v. J Med Chem. 2000. PMID: 10715145 No abstract available.

2

Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors.

Reitz DB, Li JJ, Norton MB, Reinhard EJ, Collins JT, Anderson GD, Gregory SA, Koboldt CM, Perkins WE, Seibert K, et al. Reitz DB, et al. Among authors: seibert k. J Med Chem. 1994 Nov 11;37(23):3878-81. doi: 10.1021/jm00049a005. J Med Chem. 1994. PMID: 7966148 No abstract available.

3

Diarylspiro[2.4]heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationships.

Huang HC, Li JJ, Garland DJ, Chamberlain TS, Reinhard EJ, Manning RE, Seibert K, Koboldt CM, Gregory SA, Anderson GD, Veenhuizen AW, Zhang Y, Perkins WE, Burton EG, Cogburn JN, Isakson PC, Reitz DB. Huang HC, et al. Among authors: seibert k. J Med Chem. 1996 Jan 5;39(1):253-66. doi: 10.1021/jm950664x. J Med Chem. 1996. PMID: 8568815

4

Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.

Li JJ, Norton MB, Reinhard EJ, Anderson GD, Gregory SA, Isakson PC, Koboldt CM, Masferrer JL, Perkins WE, Seibert K, Zhang Y, Zweifel BS, Reitz DB. Li JJ, et al. Among authors: seibert k. J Med Chem. 1996 Apr 26;39(9):1846-56. doi: 10.1021/jm950878e. J Med Chem. 1996. PMID: 8627608

5

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, Docter S, Graneto MJ, Lee LF, Malecha JW, Miyashiro JM, Rogers RS, Rogier DJ, Yu SS, AndersonGD, Burton EG, Cogburn JN, Gregory SA, Koboldt CM, Perkins WE, Seibert K, Veenhuizen AW, Zhang YY, Isakson PC. Penning TD, et al. Among authors: seibert k. J Med Chem. 1997 Apr 25;40(9):1347-65. doi: 10.1021/jm960803q. J Med Chem. 1997. PMID: 9135032

6

1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2.

Khanna IK, Weier RM, Yu Y, Collins PW, Miyashiro JM, Koboldt CM, Veenhuizen AW, Currie JL, Seibert K, Isakson PC. Khanna IK, et al. Among authors: seibert k. J Med Chem. 1997 May 23;40(11):1619-33. doi: 10.1021/jm970036a. J Med Chem. 1997. PMID: 9171872

7

1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents.

Khanna IK, Weier RM, Yu Y, Xu XD, Koszyk FJ, Collins PW, Koboldt CM, Veenhuizen AW, Perkins WE, Casler JJ, Masferrer JL, Zhang YY, Gregory SA, Seibert K, Isakson PC. Khanna IK, et al. Among authors: seibert k. J Med Chem. 1997 May 23;40(11):1634-47. doi: 10.1021/jm9700225. J Med Chem. 1997. PMID: 9171873

8

4,5-Diaryloxazole inhibitors of cyclooxygenase-2 (COX-2).

Talley JJ, Bertenshaw SR, Brown DL, Carter JS, Graneto MJ, Koboldt CM, Masferrer JL, Norman BH, Rogier DJ Jr, Zwwifel BS, Seibert K. Talley JJ, et al. Among authors: seibert k. Med Res Rev. 1999 May;19(3):199-208. doi: 10.1002/(sici)1098-1128(199905)19:3<199::aid-med1>3.0.co;2-7. Med Res Rev. 1999. PMID: 10232649 Review.

9

Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors.

Carter JS, Rogier DJ, Graneto MJ, Seibert K, Koboldt CM, Zhang Y, Talley JJ. Carter JS, et al. Among authors: seibert k. Bioorg Med Chem Lett. 1999 Apr 19;9(8):1167-70. doi: 10.1016/s0960-894x(99)00158-4. Bioorg Med Chem Lett. 1999. PMID: 10328306

10

Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors.

Carter JS, Kramer S, Talley JJ, Penning T, Collins P, Graneto MJ, Seibert K, Koboldt CM, Masferrer J, Zweifel B. Carter JS, et al. Among authors: seibert k. Bioorg Med Chem Lett. 1999 Apr 19;9(8):1171-4. doi: 10.1016/s0960-894x(99)00157-2. Bioorg Med Chem Lett. 1999. PMID: 10328307

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